Early Rx with losartan doesn't slow kidney disease progression

Early rx with losartan doesn't slow kidney disease progression

(HealthDay)—For American-Indians with type 2 diabetes, early administration of losartan does not slow progression of glomerular filtration rate (GFR) decline, according to a study published online Sept. 9 in Diabetes Care.

Stephanie K. Tanamas, Ph.D., from the National Institutes of Health in Phoenix, and colleagues examined whether early administration of losartan slows progression of in a six-year trial in 169 American-Indians with type 2 diabetes. Participants with urine albumin/creatinine ratio <300 mg/g were randomized to receive losartan or placebo (84 and 85, respectively). The primary outcome was a reduction in GFR to ≤60 mL/min or half the baseline value (for those who entered with GFR <120 mL/min). Participants were followed for up to 12 years post-trial, with treatment managed outside the study.

The researchers found that treatment with renin-angiotensin system inhibitors was equivalent in both groups after completion of the clinical trial. During a median of 13.5 years following randomization, 29 and 35 participants originally assigned to losartan and placebo, respectively, reached the primary GFR outcome, with a hazard ratio of 0.72 (95 percent confidence interval, 0.44 to 1.18).

"We found no evidence of an extended benefit of early losartan treatment on slowing GFR in persons with type 2 diabetes," the authors write.

The study was funded in part by Merck, which provided the study drug and placebo tablets.


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Citation: Early Rx with losartan doesn't slow kidney disease progression (2016, September 16) retrieved 8 December 2019 from https://medicalxpress.com/news/2016-09-early-rx-losartan-doesnt-kidney.html
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