Products derived from plants offer potential as dual-targeting agents for experimental cerebral malaria

Products derived from plants offer potential as dual-targeting agents for experimental cerebral malaria
Credit: McGill University

Malaria, a life-threatening disease usually caused when parasites from the Plasmodium family enter the bloodstream of a person bitten by a parasite-carrying mosquito, is a severe health threat globally, with 200 to 300 million cases annually and 445,000 deaths in 2016.

With pregnant women and children most vulnerable from infection, complications including anemia and cerebral , the most severe neurological complication from malaria, are responsible for approximately 25 percent of the in some regions of Africa.

While uncomplicated clinical malaria is treatable with antimalarial drugs, treatment options for cerebral malaria are few and those that do exist are limited in their effectiveness, a problem compounded by the emergence of resistance in the .

A recent study by researchers at McGill University conducted as a collaboration between the labs of Dr. Philippe Gros, Professor in the Department of Biochemistry and Vice-Dean, Life Science, and Dr. Jerry Pelletier, Professor in the Department of Biochemistry, shows that rocaglates – a class of naturally-derived products from plants of the Aglaia species – effectively block blood-stage parasite replication in several mouse models as well as in infected human red blood cells.

Importantly, the researchers showed that these products inhibited neurological inflammation and increased survival, including in drug-resistant isolates, highlighting the strong potential of this class of compounds to be used for therapeutic treatment of complicated malaria cases in humans.

"Rocaglates as dual-targeting agents for experimental " was published in the most recent issue of PNAS.


Explore further

Methylene blue die kills in vivo malaria parasites at speed not seen before

More information: David Langlais et al. Rocaglates as dual-targeting agents for experimental cerebral malaria, Proceedings of the National Academy of Sciences (2018). DOI: 10.1073/pnas.1713000115
Provided by McGill University
Citation: Products derived from plants offer potential as dual-targeting agents for experimental cerebral malaria (2018, February 21) retrieved 24 April 2019 from https://medicalxpress.com/news/2018-02-products-derived-potential-dual-targeting-agents.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
22 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more