The novel insights of proteoglycans in mineralized tissues

March 25, 2018, International & American Associations for Dental Research

The 47th Annual Meeting of the American Association for Dental Research (AADR), held in conjunction with the 42nd Annual Meeting of the Canadian Association for Dental Research (CADR), featured a symposium titled "The Novel Insights of Proteoglycans in Mineralized Tissues." The AADR/CADR Annual Meeting is in Fort Lauderdale, Fla. from March 21-24, 2018.

Proteoglycans are present on the cell surface and in the extracellular matrices (ECM) of all mineralized tissues, but the exact role of these heavily glycosylated proteins in bone and teeth are not well understood. In addition to being structural proteins, proteoglycans are capable of affecting both intracellular and extracellular events, such as the assembly of ECM and the transduction of signaling cascades.

"Mechanistic insights into the molecular and cellular functions of proteoglycans in mineralized tissues will reveal both the sophistication of the regulatory mechanism and the challenges that remain in uncovering the entirety of their biological functions," said session chair Xiaofang Wang, Texas A&M University College of Dentistry, Dallas. "This aims to provide an update of recent discoveries on the role of proteoglycans in mineralized tissues."

These discoveries are striking examples of proteoglycans previously ascribed functions largely structural proteins, that have now been shown to have important molecular and directing bone and tooth development. The novel insights into the understudied roles of these heavily glycosylated molecules presented in this symposium offer an exciting new frontier for scientific inquiry, especially for those with an interest in mineralized biology, craniofacial development, matrix biology and glycobiology, amongst others.

This symposium featured talks from Marian Young, National Institutes of Dental and Craniofacial Research, NIH, Bethesda, Md.; Xiaofang Wang, Texas A&M University College of Dentistry, Dallas and Shuo Chen, University of Texas at San Antonio.

Explore further: Effect of deployment on use of e-cigarettes in US military

Related Stories

Effect of deployment on use of e-cigarettes in US military

March 23, 2018
At the 47th Annual Meeting of the American Association for Dental Research (AADR), held in conjunction with the 42nd Annual Meeting of the Canadian Association for Dental Research (CADR), Prescott McWilliams, United States ...

Access and utilization of dental services for Medicaid children 2013-2015

March 23, 2018
At the 47th Annual Meeting of the American Association for Dental Research (AADR), held in conjunction with the 42nd Annual Meeting of the Canadian Association for Dental Research (CADR), Natalia I. Chalmers, D.D.S., Ph.D. ...

Effect of an opioid prescribing protocol on provider prescribing behavior

March 23, 2018
At the 47th Annual Meeting of the American Association for Dental Research (AADR), held in conjunction with the 42nd Annual Meeting of the Canadian Association for Dental Research (CADR), Chad Lowell Wagner, University of ...

Opioid abuse/dependence in those hospitalized due to periapical abscess

March 23, 2018
At the 47th Annual Meeting of the American Association for Dental Research (AADR), held in conjunction with the 42nd Annual Meeting of the Canadian Association for Dental Research (CADR), Veerasathpurush Allareddy, University ...

E-cigarette aerosol exposure causes craniofacial abnormalities in mice

March 23, 2018
At the 47th Annual Meeting of the American Association for Dental Research (AADR), held in conjunction with the 42nd Annual Meeting of the Canadian Association for Dental Research (CADR), Suraj Kandalam, Virginia Commonwealth ...

Opioid prescribing patterns of oral and maxillofacial surgeons: A nationwide survey

March 23, 2018
At the 47th Annual Meeting of the American Association for Dental Research (AADR), held in conjunction with the 42nd Annual Meeting of the Canadian Association for Dental Research (CADR), Brandon Michael Syme, University ...

Recommended for you

Researchers discover cellular messengers communicate with bacteria in the mouth

May 8, 2018
A new UCLA-led study provides clear evidence that cellular messengers in saliva may be able to regulate the growth of oral bacteria responsible for diseases, such as periodontitis and meningitis.

Drug-filled, 3-D printed dentures could fight off infections

April 25, 2018
Nearly two-thirds of the U.S. denture-wearing population suffer frequent fungal infections that cause inflammation, redness and swelling in the mouth.

Bacteria boost antifungal drug resistance in severe childhood tooth decay

April 25, 2018
Early childhood caries, a form of severe tooth decay affecting toddlers and preschoolers, can set children up for a lifetime of dental and health problems. The problem can be significant enough that surgery is the only effective ...

Absence of a transcription factor halts tooth development in mid-stride

April 11, 2018
Amjad Javed, Ph.D., and University of Alabama at Birmingham colleagues have found a key role in tooth development for the transcription factor Specificity protein 7, or Sp7.

Toothpaste alone does not prevent dental erosion or hypersensitivity

March 14, 2018
The rising prevalence of dental erosion and dentin hypersensitivity has led to the emergence of more toothpastes that claim to treat these problems. While no such toothpaste existed 20 years ago, today, many such brands are ...

Study: Absence of key protein, TTP, rapidly turns young bones old

March 10, 2018
The absence of a protein critical to the control of inflammation may lead to rapid and severe bone loss, according to a new University at Buffalo study.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.