Males with BRCA mutations have increased risk of certain cancers

April 17, 2018

(HealthDay)—Males with BRCA mutations have increased incidence of malignant disease, specifically prostate, melanoma, pancreas, and breast cancers, according to a research letter published online April 12 in JAMA Oncology.

Roy Mano, M.D., from Rabin Medical Center in Petach Tikva, Israel, and colleagues evaluated 196 male BRCA carriers (117 BRCA1 and 79 BRCA2) between February 2014 and February 2017. Using a predefined protocol, patients aged 40 years or older were screened for prostate, breast, colorectal, pancreatic, and skin malignant abnormalities.

The researchers found that 17 percent of the patients were diagnosed with 46 malignant abnormalities; 28 percent were identified during screening. At first cancer diagnosis, the median age was 54 years. Multiple malignant abnormalities were reported in seven patients, with a median of three per patient. Prostatic adenocarcinoma was the most common malignant abnormality (8.6 and 3.8 percent of BRCA1 and BRCA2 carriers, respectively). Men with BRCA mutations had a significant increase in the overall incidence of malignant disease compared with the Jewish-Israeli male population (standardized incidence ratio, 8). Elevated incidence of prostate, melanoma, pancreas, and breast cancers, but not colon cancer, was seen in association with BRCA mutations.

"Our initial findings suggest that in addition to screening for prostate and , as recommended in current guidelines, there may be a role for screening for pancreatic cancer and melanoma, whereas screening for may not be justified," the authors write.

Explore further: Busting myths surrounding cancer and genetic testing

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Busting myths surrounding cancer and genetic testing

April 13, 2018
(HealthDay)—While only 5 percent to 10 percent of cancers are caused by an inherited gene mutation, genetic testing may benefit people with a strong history of family cancer, an expert in genetics suggests.

AUA: BRCA mutations may play role in prostate cancer

May 10, 2016
(HealthDay)—A man's risk of aggressive and fatal prostate cancer may be heavily influenced by gene mutations previously linked to breast and ovarian cancer in women, a trio of new studies suggests. Findings from the studies ...

Genetic predisposition to breast cancer due to non-brca mutations in ashkenazi Jewish women

July 20, 2017
Genetic mutations in BRCA1 and BRCA2 increase the risk of breast and ovarian cancer in Ashkenazi Jewish women. A new article published by JAMA Oncology examines the likelihood of carrying another cancer-predisposing mutation ...

Breast cancer gene does not boost risk of death: study

January 12, 2018
Young women with the BRCA gene mutation that prompted actress Angelina Jolie's pre-emptive and much-publicised double mastectomy are not more likely to die after a breast cancer diagnosis, scientists said Friday.

Mutations common in pancreatic CA, history of other cancers

February 7, 2018
(HealthDay)—A substantial proportion of individuals with pancreatic cancer and a history of other hereditary breast and ovarian cancer (HBOC)- or Lynch syndrome (LS)-related cancers have mutations in a prostate cancer susceptibility ...

Recommended for you

In zebrafish, a way to find new cancer therapies, targeting tumor modulators

September 21, 2018
The lab of Leonard Zon, MD, at Boston Children's Hospital has long been interested in making blood stem cells in quantity for therapeutic purposes. Looking for a way to test for their presence in zebrafish, their go-to research ...

What can salad dressing tell us about cancer? Think oil and vinegar

September 20, 2018
Researchers led by St. Jude Children's Research Hospital scientists have identified another way the process that causes oil to form droplets in water may contribute to solid tumors, such as prostate and breast cancer. The ...

Novel biomarker found in ovarian cancer patients can predict response to therapy

September 20, 2018
Despite months of aggressive treatment involving surgery and chemotherapy, about 85 percent of women with high-grade wide-spread ovarian cancer will have a recurrence of their disease. This leads to further treatment, but ...

Testing fluorescent tracers used to help surgeons determine edges of breast cancer tumors

September 20, 2018
A team of researchers with members from institutions in The Netherlands and China has conducted a test of fluorescent tracers meant to aid surgeons performing tumor removal in breast cancer patients. In their paper published ...

Cancer immunotherapy might benefit from previously overlooked immune players

September 20, 2018
Cancer immunotherapy—efforts to boost a patient's own immune system, allowing it to better fight cancer cells on its own—has shown great promise for some previously intractable cancers. Yet immunotherapy doesn't work ...

New way to target advanced breast cancers

September 20, 2018
A cytokine signature found in certain kinds of breast cancer cells can not only serve as a diagnostic tool for HER2-negative cancers but also offer an effective treatment target.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.