Certain medications for chronic inflammatory diseases appear safe during pregnancy

Anti-tumor necrosis factor medications (anti-TNFs) are effective in controlling chronic inflammatory diseases, but some physicians recommend that their patients discontinue them during pregnancy. In an Arthritis & Rheumatology analysis of 528 pregnancies of women exposed to certolizumab pegol (CZP), an anti-TNF approved for treatment of rheumatic diseases and/or Crohn's disease, 85% of pregnancies resulted in live births, and the rate of major congenital malformations (2%) was similar to those reported for the general population in the United States and Europe.

These findings are reassuring for women of childbearing age affected by considering treatment with CZP who wish to become or are pregnant.

"In this large study of pregnancies, it appears that taking CZP during pregnancy did not increase the chances for pregnancy loss, preterm birth, or birth defects," said lead author Dr. Megan Clowse, of Duke University Medical Center. "Continuing anti-TNFs in pregnancy has been recommended for many years for women with Crohn's Disease, and these data suggest that it is also safe for women with other , such as ."


Explore further

Birth defects not up significantly with anti-TNFs in pregnancy

More information: Arthritis & Rheumatology , DOI: 10.1002/art.40508
Provided by Wiley
Citation: Certain medications for chronic inflammatory diseases appear safe during pregnancy (2018, April 5) retrieved 23 January 2019 from https://medicalxpress.com/news/2018-04-medications-chronic-inflammatory-diseases-safe.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
4 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more