Metabolic syndrome common with chronic hep B infection

April 17, 2018

(HealthDay)—Metabolic syndrome (MetS) is prevalent among patients with chronic hepatitis B (HBV) infection, according to a study published online March 29 in Diabetes Care.

Mandana Khalili, M.D., from the University of California, San Francisco, and colleagues assessed prevalence of MetS and its influence on alanine aminotransferase (ALT) levels and fibrosis among a multiethnic North American cohort with chronic HBV infection (777 patients).

The researchers found that 22 percent of patients with chronic HBV had MetS. MetS was associated with age ( 54.4, versus 40.2 years without MetS) and sex (61 percent male). At baseline, MetS was not associated with ALT or aspartate aminotransferase-to-platelet ratio index (APRI). However, ALT was significantly higher (P = 0.02) among those with MetS at baseline, and even higher (P = 0.003) among those with persistent MetS in adjusted multivariable analysis of serial ALT values. At follow-up, MetS was not associated with serial APRI.

"MetS was prevalent in this HBV cohort and was independently associated with higher ALT levels longitudinally," the authors write. "These findings highlight the importance of screening for MetS and the potential for MetS to influence ALT and its interpretation in the context of HBV treatment decisions."

Several authors disclosed financial ties to the pharmaceutical industry.

Explore further: Chemo ups metabolic syndrome risk in early-stage breast cancer

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Chemo ups metabolic syndrome risk in early-stage breast cancer

June 9, 2016
(HealthDay)—For patients with early-stage breast cancer with no preexisting metabolic syndrome (MetS), chemotherapy is associated with increased risk of MetS, according to a study published online May 24 in Cancer.

Fatty liver may directly mediate CAD in metabolic syndrome

January 23, 2013
(HealthDay)—Men and women with fatty liver are more likely to have metabolic syndrome (MetS) with type 2 diabetes, and women with fatty liver are more likely to have MetS with subclinical atherosclerosis, according to research ...

Higher oxidative stress linked to metabolic syndrome

December 22, 2016
(HealthDay)—Oxidized low-density lipoprotein (ox-LDL) as a proxy for oxidative stress is associated with metabolic syndrome (MetS) and its components, according to a study published online Dec. 19 in Diabetes.

Metabolic syndrome tied to risk of mild cognitive impairment

March 2, 2016
(HealthDay)—The incidence of mild cognitive impairment (MCI) and MCI progression to dementia is increased in association with metabolic syndrome (MetS), according to a study published online Feb. 29 in JAMA Neurology.

Socioeconomic status in children tied to MetS in adulthood

October 28, 2016
(HealthDay)—Family socioeconomic status (SES) in childhood is associated with the risk for metabolic syndrome (MetS) and glucose abnormalities in adulthood, according to a study published online Oct. 18 in Diabetes Care.

Heart disease patients less likely to die of cancer if they are fit

December 11, 2017
Heart disease patients are less likely to die of cancer if they are fit, suggests an observational study in more than 12 000 patients presented today at EuroEcho-Imaging 2017.

Recommended for you

Genomic study brings us closer to precision medicine for type 2 diabetes

September 21, 2018
Most patients diagnosed with type 2 diabetes are treated with a "one-size-fits-all" protocol that is not tailored to each person's physiology and may leave many cases inadequately managed. A new study by scientists at the ...

High gluten diet in pregnancy linked to increased risk of diabetes in children

September 19, 2018
A high gluten intake by mothers during pregnancy is associated with an increased risk of their child developing type 1 diabetes, suggests a study published by The BMJ today.

Anti-inflammatory protein promotes healthy gut bacteria to curb obesity

September 19, 2018
Scientists from the UNC School of Medicine discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet. The researchers also reported ...

Study reveals the current rates of diagnosed type 1 and type 2 diabetes in American adults

September 18, 2018
A new study from the University of Iowa finds that type 2 diabetes remains overwhelmingly the most common type of diabetes diagnosed in American adults who have the disease.

Research reveals link between immunity, diabetes

September 14, 2018
When it comes to diet-induced obesity, your immune system is not always your friend.

BPA exposure in U.S.-approved levels may alter insulin response in non-diabetic adults

September 14, 2018
In a first study of its kind study, researchers have found that a common chemical consumers are exposed to several times a day may be altering insulin release. Results of the study, led by scientists at the University of ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.