Dual-hormone system may lower time in hypoglycemia in T1DM

May 16, 2018

(HealthDay)—For physically active adults with type 1 diabetes, the addition of glucagon delivery to a closed-loop system using wearable sensors with automated exercise detection is associated with reduced hypoglycemia, according to a study published online May 11 in Diabetes Care.

Jessica R. Castle, M.D., from the Oregon Health & Science University in Portland, and colleagues enrolled 20 participants with type 1 . Participants underwent dual-hormone, single-hormone, predictive low glucose suspend, and continuation of current care over four days in a randomized order. Three moderate-intensity aerobic exercise sessions were included in each arm.

The researchers found that the lowest mean time in hypoglycemia was seen with dual-hormone during the exercise period (3.4 percent versus 8.3 [P = 0.009], 7.6 [P < 0.001], and 4.3 percent [P = 0.49] for single-hormone, predictive low glucose suspend, and current care, respectively). During the entire four-day study, time in hypoglycemia was also lowest with dual-hormone (1.3 percent versus 2.8 [P < 0.001), 2.0 [P = 0.04], and 3.1 percent [P = 0.007] for single-hormone, predictive low glucose suspend, and current care, respectively). During the entire study, time in range was the highest with single-hormone (74.3 percent, versus 72.0 percent with dual-hormone; P = 0.44).

"The addition of glucagon delivery to a closed-loop system with automated detection reduces in physically active adults with type 1 diabetes," the authors write.

Two authors disclosed financial ties to Pacific Diabetes Technologies.

Explore further: Closed-loop insulin delivery promising in T1DM pregnancy

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Closed-loop insulin delivery promising in T1DM pregnancy

March 16, 2018
(HealthDay)—For pregnant women with type 1 diabetes, a closed-loop system is associated with comparable glucose control and significantly less hypoglycemia than sensor-augmented pump (SAP) therapy, according to a study ...

Similar defects ID'd for T2DM, chronic pancreatitis and diabetes

August 2, 2017
(HealthDay)—Patients with type 2 diabetes and those with diabetes secondary to chronic pancreatitis have similarly impaired α-cell responses to oral glucose ingestion and hypoglycemia, according to a study published online ...

Artificial pancreas protocol deemed feasible for younger kids

May 13, 2016
(HealthDay)—A child-specific version of the modular model predictive control (MMPC) algorithm is feasible and safe for 5- to 9-year-old children with type 1 diabetes, according to the first outpatient single-hormone artificial ...

Dual-hormone artificial pancreas is a step closer for patients with Type 1 diabetes

January 28, 2013
For patients with type 1 diabetes, a dual-hormone artificial pancreas system (also known as a closed-loop delivery system) improved the control of glucose levels and reduced the risk of hypoglycemia compared with conventional ...

Closed-loop control benefits T1DM in prolonged winter sport

September 18, 2017
(HealthDay)—For adolescents with type 1 diabetes (T1D), a closed-loop control (CLC) system is associated with improved glycemic control and reduced exposure to hypoglycemia during prolonged exercise, cold temperatures, ...

Intense interval training cuts hypoglycemia awareness in T1DM

May 2, 2017
(HealthDay)—For patients with type 1 diabetes and normal awareness of hypoglycemia (NAH), high-intensity interval training (HIIT) is associated with reduced awareness of subsequent hypoglycemia, according to a study published ...

Recommended for you

Genomic study brings us closer to precision medicine for type 2 diabetes

September 21, 2018
Most patients diagnosed with type 2 diabetes are treated with a "one-size-fits-all" protocol that is not tailored to each person's physiology and may leave many cases inadequately managed. A new study by scientists at the ...

High gluten diet in pregnancy linked to increased risk of diabetes in children

September 19, 2018
A high gluten intake by mothers during pregnancy is associated with an increased risk of their child developing type 1 diabetes, suggests a study published by The BMJ today.

Anti-inflammatory protein promotes healthy gut bacteria to curb obesity

September 19, 2018
Scientists from the UNC School of Medicine discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet. The researchers also reported ...

Study reveals the current rates of diagnosed type 1 and type 2 diabetes in American adults

September 18, 2018
A new study from the University of Iowa finds that type 2 diabetes remains overwhelmingly the most common type of diabetes diagnosed in American adults who have the disease.

Research reveals link between immunity, diabetes

September 14, 2018
When it comes to diet-induced obesity, your immune system is not always your friend.

BPA exposure in U.S.-approved levels may alter insulin response in non-diabetic adults

September 14, 2018
In a first study of its kind study, researchers have found that a common chemical consumers are exposed to several times a day may be altering insulin release. Results of the study, led by scientists at the University of ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.