Early intervention services best for early-phase psychosis

May 7, 2018

(HealthDay)—Early intervention services (EIS) are better than treatment as usual (TAU) for early-phase psychosis across meta-analyzable outcomes, according to a review published online May 2 in JAMA Psychiatry.

Christoph U. Correll, M.D., from The Zucker Hillside Hospital in Glen Oaks, N.Y., and colleagues conducted a systematic literature review to compare EIS with TAU for early-phase psychosis. Data were included for 10 among 2,176 patients.

The researchers found that for all 13 meta-analyzable outcomes, EIS were correlated with better outcomes than TAU at the end of treatment. The outcomes included discontinuation of all-cause treatment (risk ratio, 0.7), at least one psychiatric hospitalization (risk ratio, 0.74), involvement in school or work (risk ratio, 1.13), total severity (standardized mean difference [SMD], −0.32), and positive and negative symptom severity (SMD, −0.22 and −0.28, respectively). At six, nine to 12, and 18 to 24 months of , the superiority of EIS regarding all outcomes was evident apart from general symptom and depressive symptom severity at 18 to 24 months.

"In early-phase psychosis, EIS are superior to TAU across all meta-analyzable outcomes," the authors write. "These results support the need for funding and use of EIS in patients with early-phase psychosis."

Several authors disclosed financial ties to the pharmaceutical industry.

Explore further: Functional outcome explored in those at risk for psychosis

More information: Abstract/Full Text
Editorial (subscription or payment may be required)

Related Stories

Functional outcome explored in those at risk for psychosis

September 7, 2013
(HealthDay)—Measures of social and role functioning predict functional outcome in those at clinical high risk for psychosis, and poor functional outcome is not entirely dependent on conversion to full-blown disease, according ...

Thalamic dysconnectivity seen in those at risk for psychosis

August 13, 2015
(HealthDay)—Among individuals at clinical high risk for psychosis, thalamic dysconnectivity is evident, according to a study published online Aug. 12 in JAMA Psychiatry.

Internet-based CBT effective for depressive symptoms

February 25, 2017
(HealthDay)—Self-guided internet-based cognitive behavioral therapy (iCBT) is effective for treating adults with depressive symptoms, according to a review published online Feb. 22 in JAMA Psychiatry.

Antioxidants and amino acids could play role in the treatment of psychosis

March 22, 2018
A scientific paper has revealed that some nutrients found in food may help reduce the symptoms of psychotic illness, when used in the early stages of treatment.

Antidepressant efficacy varies for depressive symptom clusters

February 28, 2017
(HealthDay)—Antidepressant treatment efficacy varies for empirically-defined clusters of symptoms, according to a study published online Feb. 22 in JAMA Psychiatry.

Review: similar / improved outcomes for TAVI versus SAVR

June 7, 2016
(HealthDay)—Transcatheter aortic valve implantation (TAVI) may be associated with improved clinical outcomes versus surgical aortic valve replacement (SAVR) in adults with severe aortic stenosis, according to a review and ...

Recommended for you

Sensitive babies become altruistic toddlers

September 25, 2018
Our responsiveness to seeing others in distress accounts for variability in helping behavior from early in development, according to a study published September 25 in the open-access journal PLOS Biology by Tobias Grossmann ...

Evidence that increased BMI causes lower mental wellbeing

September 25, 2018
There is an increasing need to prevent obesity because of the consequences for mental as well as physical health, new research by academics at the University of Bristol has found.

Insomnia symptoms, overall health improve with online insomnia program

September 25, 2018
Treating insomnia with digital programs can improve insomnia symptoms, daytime functioning and overall health, a new study from the University of Oxford and Northwestern Medicine has found.

Researchers reveal link between hunger and mood, new study

September 25, 2018
It seems "hangry" isn't just a made-up term.

Baby sleeping in the parental bedroom not related to later behavioural problems

September 25, 2018
Sleeping in the parental bedroom as a baby is not related to sleeping problems or behavioural problems later in life. Moreover, there are indications that room-sharing may even be related to positive outcomes, such as improved ...

Gender 'nonconformity' takes mental toll on teens

September 25, 2018
(HealthDay)—American teens whose behavior, appearance or lifestyle do not conform to widely held views on what it is to be a "normal" male or female face a high risk for mental distress and drug abuse, new research warns.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.