Restricting fluids post abdominal surgery doesn't up survival
Paul S. Myles, M.P.H., D.Sc., from Monash University in Melbourne, Australia, and colleagues randomized 3,000 patients who had an increased risk of complications while undergoing major abdominal surgery to receive a restrictive or liberal intravenous-fluid regimen during and up to 24 hours after surgery (1,490 and 1,493 patients, respectively).
The researchers found that at one-year, the rate of disability-free survival was 81.9 and 82.3 percent in the restrictive and liberal fluid groups, respectively (hazard ratio for death or disability, 1.05; 95 percent confidence interval, 0.88 to 1.24; P = 0.61). The rate of acute kidney injury was 8.6 and 5.0 percent in the restrictive and liberal fluid groups, respectively (P < 0.001).
"Among patients at increased risk for complications during major abdominal surgery, a restrictive fluid regimen was not associated with a higher rate of disability-free survival than a liberal fluid regimen and was associated with a higher rate of acute kidney injury," the authors write.
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