Very-low-carb diet shows promise in type 1 diabetes

May 7, 2018, Children's Hospital Boston
Credit: CC0 Public Domain

Very-low-carbohydrate diets can improve blood sugar control in type 1 diabetes, with low rates of hypoglycemia and other complications, according to an online patient survey. The researchers, led by Belinda Lennerz, MD, PhD, and David Ludwig, MD, PhD, of Boston Children's Hospital, now call for controlled clinical trials of this approach.

Findings were reported today in the journal Pediatrics.

The patients were drawn from TypeOneGrit, a Facebook community of people with type 1 diabetes committed to a very-low-carb diet as recommended by the book Dr. Bernstein's Diabetes Solution (Richard Bernstein, MD, is a co-author on the study).

Of 493 people who took the survey, 316 provided enough information to be included in the analysis. For 138 of these participants, the researchers were able to confirm diabetes diagnosis, blood-sugar control measures, metabolic health measures and other outcomes with health care providers or through review of medical records. Forty-two percent of participants were children.

Participants reported an average daily carbohydrate intake of 36 grams, or about 5 percent of total calories (for comparison, the American Diabetes Association recommends about 45 percent of calories come from carbohydrates). Self-reported hemoglobin A1c values—the primary measure of —averaged in the normal range, at 5.67 percent (the target is below 7 percent and prevailing levels average 8.2 percent).

Participants required lower-than-average doses of insulin (mean, 0.40 U/kg/day), and those for whom data were available had favorable measures of insulin sensitivity and cardiometabolic health, such as low triglyceride levels and high HDL cholesterol levels.

Low-carb controversy

Safety concerns have been raised about very-low-carb diets in type 1 diabetes, primarily that they increase the risk of hypoglycemia, or dangerous drops in blood sugar. However, in the study, rates of hospitalization for hypoglycemia (1 percent), diabetic ketoacidosis (2 percent) and other were lower than those generally reported for type 1 diabetes populations.

More than 80 percent of survey respondents were satisfied or very satisfied with their diabetes management. Yet about a quarter said they did not discuss the very-low-carb diet with their diabetes care providers, some citing concerns about being criticized or even being accused of child abuse.

The study authors note that severe carbohydrate restriction is actually a very old approach in type 1 diabetes.1 Before the discovery of insulin, it extended children's lives, sometimes for years. Once insulin was introduced, carb restriction fell out of practice.

But the authors believe very-low-carbohydrate diets deserve further study in type 1 diabetes. Since this study was observational in nature and not controlled, they call for randomized clinical trials to rigorously test the diet's safety and efficacy.

Lennerz and Ludwig emphasize that the results of this study, by themselves, do not justify a change in . They strongly suggest that anyone with diabetes make dietary changes only with the supervision of a care provider.

Explore further: Insulin pumps associated with lower risk of serious complications among young patients with type 1 diabetes

More information: Belinda S. Lennerz et al, Management of Type 1 Diabetes With a Very Low–Carbohydrate Diet, Pediatrics (2018). DOI: 10.1542/peds.2017-3349

1. Newburgh LH, Marsh PL. The use of a high fat diet in the treatment of diabetes mellitus. Arch Intern Med 1921; 27(6):699-705

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EnricM
not rated yet May 08, 2018
Hmmm, I see a fad diet in the horizon.
That's how it starts.

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