Mitochondrial dysfunction contributes to kidney disease

kidney
Credit: CC0 Public Domain

Scientists found a previously unknown link between mitochondria and kidney disease, identifying a receptor that causes kidney dysfunction when suppressed, according to a study published in Proceedings of the National Academy of Sciences.

The receptor—estrogen-related receptor gamma (ERRγ)—regulates mitochondrial metabolism, and was also found in unusually low levels in patients with chronic , pointing to its importance in healthy kidney function. Grant Barish, MD, assistant professor of Medicine in the Division of Endocrinology, Metabolism, and Molecular Medicine, and Amanda Allred and Yasuhiro Omura, research technologists in the Barish laboratory, were co-authors of the study.

Mitochondria are the power plants of the cell, breaking down nutrients and converting them to chemical energy used in a variety of processes. Mutations in mitochondria can reduce their effectiveness, causing dysfunction in organs with high energetic demand such as the heart or kidneys.

Kidneys recycle electrolytes and glucose, part of their role of filtering blood, and have a high density of mitochondria to power that absorption—accordingly, the absorption function is especially vulnerable to mitochondrial impairment.

Prior to the study, the specific molecular mechanisms linking dysfunctional mitochondria to impaired reabsorption were poorly understood. ERRγ has recently emerged as a key regulator of and previous studies have linked ERRγ to kidney development, but definitive evidence had yet to emerge for its role in disease.

In the current study, scientists found that ERRγ not only directly regulates kidney mitochondrial metabolism but also controls the abundance of renal solute carriers and pumps with another transcription factor called HNF1Β. Deletion of ERRγ results in comparable to that seen in models with loss-of-function mutations in HNF1Β, further supporting the link between ERRγ and HNF1Β.

ERRγ is a critical molecule linking energy-producing and energy-consuming functions in the , according to the authors.


Explore further

Scientists find power switch for muscles

More information: Juanjuan Zhao et al. Genomic integration of ERRγ-HNF1β regulates renal bioenergetics and prevents chronic kidney disease, Proceedings of the National Academy of Sciences (2018). DOI: 10.1073/pnas.1804965115
Provided by Northwestern University
Citation: Mitochondrial dysfunction contributes to kidney disease (2018, June 8) retrieved 20 March 2019 from https://medicalxpress.com/news/2018-06-mitochondrial-dysfunction-contributes-kidney-disease.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
221 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more