T2DM risk in offspring greater with T2DM versus GDM exposure

June 14, 2018

(HealthDay)—In utero exposure to type 2 diabetes is associated with increased risk of type 2 diabetes in offspring versus exposure to gestational diabetes, according to a study published online June 11 in JAMA Pediatrics.

Brandy A. Wicklow, M.D., from the University of Manitoba in Winnipeg, Canada, and colleagues examined the correlation of in utero exposure to and type 2 diabetes with the development of type 2 diabetes in , stratified by First Nations (FN) status. A pediatric diabetes clinical database was linked to a population-based research data repository; the cohort study included 467,850 offspring.

The researchers found that after adjustment for sex, maternal age, socioeconomic status, birth size, and gestational age, FN status and diabetes exposure were correlated with incident type 2 diabetes in offspring. The risk to offspring was greater with type 2 diabetes exposure versus gestational diabetes exposure (3.19 versus 0.8 cases per 1,000 person-years). Any diabetes exposure was correlated with accelerated time to the development of type 2 diabetes in offspring by a factor of 0.74 and 0.5 for gestational diabetes and type 2 diabetes, respectively, compared with no diabetes exposure. Risk was higher for FN offspring versus non-FN offspring (0.96 versus 0.14 cases per 1,000 person-years). The interactions between FN and type 2 diabetes and FN and gestational diabetes were not significant.

"Important differences exist in offspring risk based on type of in utero," the authors write.

Explore further: Type 2 diabetes ups risk of renal cancer in women, but not men

More information: Abstract/Full Text

Related Stories

Type 2 diabetes ups risk of renal cancer in women, but not men

May 8, 2018
(HealthDay)—Type 2 diabetes is independently associated with a greater risk of renal cell carcinoma (RCC) in women, but not in men, according to a study published online April 20 in Diabetes Care.

Parental type 1 diabetes may increase offspring risk for ADHD

February 4, 2018
(HealthDay)—Children whose parents have type 1 diabetes (T1D) have a higher risk of being diagnosed with attention-deficit/hyperactivity disorder (ADHD), according to a study published online Jan. 26 in Diabetes Care.

Chronic hepatitis B prevalence higher in those with T2DM

December 23, 2016
(HealthDay)—Patients with type 2 diabetes have higher prevalence of chronic hepatitis B virus infection (CHB), according to a study published online Dec. 8 in the Journal of Diabetes Investigation.

Fetal hemoglobin glycation may reflect hyperglycemia in utero

July 21, 2014
(HealthDay)—Glycation of the α-chain (Glα) in fetal hemoglobin is higher in neonates from women with gestational diabetes mellitus and may reflect hyperglycemia exposure in utero, according to a study published online ...

Maternal overweight and obesity increases risk of type 1 diabetes in children when neither parent has diabetes

April 27, 2015
A study of more than 1.2 million children in Sweden has concluded that children of parents with any type of diabetes are more likely to develop type 1 diabetes (T1D), and that maternal overweight and obesity increases the ...

Maternal low protein diet promotes diabetic phenotypes in offspring

September 2, 2014
Millions of people throughout the world are affected by diabetes. In particular, the rise in the incidence of type 2 diabetes is associated with global increases in obesity and changes in diet. There is also a genetic component ...

Recommended for you

Genetic determinants of telomere length in African American youth

September 25, 2018
Telomeres are DNA-protein structures that play a vital role in maintaining DNA stability and integrity. Telomere length (TL) is an important biomarker of aging and overall health, but TL has been mostly studied in adult populations ...

Method identified to reduce risk of brain damage in leukemia survivors

September 25, 2018
Children with acute lymphoblastic leukemia (ALL) are at an extremely high risk of sepsis compared to the general population. In the first-published study of its kind, St. Jude Children's Research Hospital scientists have ...

Newborn jaundice treatment may increase risk of childhood seizures

September 25, 2018
New research suggests that phototherapy – a treatment for newborns with jaundice – could increase children's risk of developing epilepsy. The finding raises concerns about babies being given the treatment when it's not ...

Baby sleeping in the parental bedroom not related to later behavioural problems

September 25, 2018
Sleeping in the parental bedroom as a baby is not related to sleeping problems or behavioural problems later in life. Moreover, there are indications that room-sharing may even be related to positive outcomes, such as improved ...

Gender 'nonconformity' takes mental toll on teens

September 25, 2018
(HealthDay)—American teens whose behavior, appearance or lifestyle do not conform to widely held views on what it is to be a "normal" male or female face a high risk for mental distress and drug abuse, new research warns.

Exposure to farmyard bugs reduces immune overreaction found in childhood asthma

September 24, 2018
Treating new born mice with farmyard microbes reduces wheezing and inflammation in the airways, by 'taming' their immune systems.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.