Circadian system, misalignment have distinct impact on insulin

July 11, 2018

(HealthDay)—The endogenous circadian system, behavioral cycle, and circadian misalignment have distinct effects on insulin sensitivity and β-cell function, according to a study published online June 4 in Diabetes, Obesity and Metabolism.

Noting that shift workers, who experience circadian misalignment, have an increased risk of type 2 diabetes, Jingyi Qian, Ph.D., from Brigham and Women's Hospital in Boston, and colleagues examined the separate and relative impacts of the circadian system, behavioral/environmental cycles, and their interaction (circadian misalignment) on insulin sensitivity and β-cell function. The major determinants of were quantitatively assessed in 14 healthy adults using a randomized, crossover design with two eight-day laboratory protocols that involved three baseline inpatient days with habitual sleep/wake cycles followed by four inpatient days with the same nocturnal bedtime or with 12-hour inverted behavioral/environmental cycles.

The researchers found that circadian phase and circadian misalignment impact tolerance through different mechanisms. The circadian system mainly decreases both dynamic and static β-cell responsivity to reduce glucose tolerance in the biological evening versus the biological morning. In contrast, circadian misalignment did not affect β-cell function but reduced glucose tolerance mainly by lowering insulin sensitivity.

"The results show separate effects of the endogenous circadian system, the behavioral , and on and β-cell responsivity with relevance for daily glucose regulation in diurnally active people as well as night-shift workers," the authors write.

Two authors disclosed financial ties to the pharmaceutical and nutrition industries.

Explore further: Circadian misalignment may impact diabetes risk

More information: Abstract/Full Text

Related Stories

Circadian misalignment may impact diabetes risk

June 4, 2014
(HealthDay)—Circadian misalignment decreases insulin sensitivity and increases inflammation, and is independent of sleep loss in men, according to a study published in the June issue of Diabetes.

Study may help explain increased risk of diabetes in shift workers

April 14, 2015
A new study may help explain why glucose tolerance—the ability to regulate blood-sugar levels—is lower at dinner than at breakfast for healthy people, and why shift workers are at increased risk of diabetes.

Circadian misalignment helps explain higher risk for cardiovascular disease

February 8, 2016
Shift workers frequently undergo circadian misalignment, disruption of the "body clock," caused by inverted wake and sleep cycles. Although shift work, which requires workers to be awake when the brain's circadian clock is ...

Fat tissue shows a robust circadian rhythm in a dish

June 7, 2016
In humans, glucose tolerance varies with time of day, but the mechanism responsible for the variation in insulin sensitivity throughout the day is unclear. In a recent study in The Journal of the Federation of American Societies ...

Insufficient sleep cycle—especially for shift workers—may increase heart disease risk

June 6, 2016
The body's involuntary processes may malfunction in shift workers and other chronically sleep-deprived people, and may lead to an increased risk of cardiovascular disease, according to new research in the American Heart Association's ...

Recommended for you

Wound care revolution: Put away your rulers and reach for your phone

December 18, 2018
Monitoring a wound is critical, especially in diabetic patients, whose lack of sensation due to nerve damage can lead to infection of a lesion and, ultimately, amputation. Clinicians and healthcare professionals at the McGill ...

Does diabetes damage brain health?

December 14, 2018
(HealthDay)—Diabetes has been tied to a number of complications such as kidney disease, but new research has found that older people with type 2 diabetes can also have more difficulties with thinking and memory.

Researchers study abnormal blood glucose levels of discharged patients

December 14, 2018
University of Minnesota Medical School researchers decided to delve into an area where little data currently exists. They wanted to know what happens after these patients with abnormal blood glucose measurements are discharged? ...

Researchers zero in on potential therapeutic target for diabetes, associated diseases

December 14, 2018
A recent study led by researchers in Texas A&M University's department of nutrition and food science shows how a novel regulatory mechanism serves as an important biomarker for the development of diabetes, as well as a potential ...

Researchers have found that incidence of heart failure was around two-fold higher in people with diabetes

December 11, 2018
Researchers have found that incidence of heart failure was around two-fold higher in people with diabetes.

Millions of low-risk people with diabetes may be testing their blood sugar too often

December 10, 2018
For people with Type 2 diabetes, the task of testing their blood sugar with a fingertip prick and a drop of blood on a special strip of paper becomes part of everyday life.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.