Reproductive, hormonal factors tied to knee OA in women

July 24, 2018

(HealthDay)—Female reproductive and hormonal factors are associated with incidence of knee osteoarthritis (OA), according to a study published in the July issue of Arthritis & Rheumatology.

Sultana Monira Hussain, M.B.B.S, M.P.H., Ph.D., from Monash University in Melbourne, Australia, and colleagues examined associations between female reproductive and hormonal factors (measured between 1990 and 1994) and incidence of (TKA) for OA among 22,289 women participating in the Melbourne Collaborative Cohort Study. Analyses were adjusted for age, (BMI) at midlife, change in BMI from early reproductive age to midlife, country of birth, physical activity, smoking, and education level.

The researchers identified 1,208 TKAs for OA over 12.7 years. There was an increased risk of TKA among those ever having being pregnant (hazard ratio [HR], 1.32; 95 percent confidence interval [CI], 1.06 to 1.63). Parity also was associated with an increased risk of TKA. Oral contraceptive (OC) users had an increased risk of TKA versus non-users (OC use of less than five years: HR, 1.25 [95 percent CI, 1.08 to 1.45]; OC use of five or more years: HR, 1.17 [95 percent CI, 1.0 to 1.37]). There was a decrease in TKA risk for each one-year increase in menstruation (HR, 0.99; 95 percent CI, 0.97 to 0.99). However, with adjustments, these associations remained significant only for women of normal weight at early reproductive age. Users of had an increased risk of TKA (HR, 1.37; 95 percent CI, 1.14 to 1.64), though this association was significant only for non-obese women at midlife.

"Reproductive and hormonal factors were associated with risk of knee OA," the authors write."Further work is needed to understand the complex effect of these factors on OA."

Explore further: Reproductive markers associated with risk of diabetes

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Reproductive markers associated with risk of diabetes

May 3, 2018
(HealthDay)—Markers of reproductive history, including age of menarche and parity, may be tied to future diabetes risk in women with a body mass index (BMI) ≥25 kg/m², according to a study published in Diabetes, Obesity ...

Unfavorable prepregnancy lipid levels linked to low parity

July 23, 2018
(HealthDay)—The risk of having no or only one child is elevated for women with an unfavorable prepregnancy lipid profile, according to a study published in the June issue of BMJ Open.

Overweight/obesity up incidence of hand, hip, knee osteoarthritis

August 3, 2016
(HealthDay)—The incidence of hand, hip, and knee osteoarthritis (OA) increases with overweight and obesity, particularly in the knee, according to a study published in the August issue of Arthritis & Rheumatology.

Knee, hip arthroplasty tied to increased short-term MI risk

October 22, 2015
(HealthDay)—For patients undergoing total knee arthroplasty (TKA) and total hip arthroplasty (THA) for osteoarthritis, the risk of myocardial infarction (MI) is increased in the first postoperative month, according to a ...

Physical activity linked to lower mortality risk in CHD

March 21, 2018
(HealthDay)—Physical activity (PA), but not weight loss, is associated with improved survival in coronary heart disease (CHD), according to a study published in the March 13 issue of the Journal of the American College ...

Finger length a 'pointer' to Osteoarthritis

March 31, 2014
(Medical Xpress)—Our fingers could be more important than we think. New research has revealed that the length of a person's finger could become a 'pointer' to their risk factor in developing osteoarthritis later in life.

Recommended for you

Dietary carbohydrates could lead to osteoarthritis, new study finds

August 9, 2018
Do your knees ache? According to new findings from the Oklahoma Medical Research Foundation, your diet could be a culprit.

Joint study raises questions about treatments for arthritis

August 3, 2018
A study examining how molecules are transported into knee-joint tissue could have major implications for understanding and treating arthritis.

Researchers identify new arthritis severity gene

July 26, 2018
A new gene associated with disease severity in models of rheumatoid arthritis has been identified by researchers at the Icahn School of Medicine at Mount Sinai. The discovery could provide a new pathway for treatment and ...

How the brain plays a role in rheumatoid arthritis inflammation

June 18, 2018
In patients with chronic inflammatory conditions, such as rheumatoid arthritis, there has been limited understanding of how this inflammation affects the brain.

New 3-D imaging analysis technique could lead to improved arthritis treatment

June 18, 2018
An algorithm to monitor the joints of patients with arthritis, which could change the way that the severity of the condition is assessed, has been developed by a team of engineers, physicians and radiologists led by the University ...

Joint resolution: A link between Huntington's disease and rheumatoid arthritis

May 15, 2018
Using new analytic tools, researchers at University of California San Diego School of Medicine and the Icahn School of Medicine at Mount Sinai have decoded the epigenetic landscape for rheumatoid arthritis (RA), a common ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.