TGFB1 mutation ups radiation-induced breast fibrosis risk
Aaron J. Grossberg, M.D., Ph.D., from the University of Texas MD Anderson Cancer Center in Houston, and colleagues examined the correlation between the C-509T variant allele in the promoter region of TGFB1 and breast fibrosis three years after radiotherapy in a cohort study nested in an open-label, randomized clinical trial that compared hypofractionated whole-breast irradiation (WBI) with conventionally fractionated WBI. Two hundred eighty-seven women aged 40 years or older with pathologically confirmed stage 0 to IIA breast cancer treated with breast-conserving surgery were enrolled and observed for a minimum of three years.
TGFB1 genotype and three-year radiotherapy-induced toxicity data were available for 174 patients, 51 percent of whom had at least one copy of C-509T. The researchers found that 13.8 percent of patients with C-509T and 3.8 percent of those without the allele variant had grade 2 or higher breast fibrosis. In multivariable analysis, the only factors significantly associated with breast fibrosis risk were C-509T and postoperative cosmetic outcomes (odds ratios, 4.47 and 7.09, respectively).
"The C-509T allele in TGFB1 is a key determinant of breast fibrosis risk," the authors write. "Assessing TGFB1 genotype may facilitate a more personalized approach to locoregional treatment decisions in breast cancer."
Two authors disclosed financial ties to the pharmaceutical and medical device industries.
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