Thyroid dysfunction linked to gestational diabetes

August 7, 2018

(HealthDay)—Higher free triiodothyronine (fT3) levels, but not free thyroxine (fT4) or thyroid-stimulating hormone (TSH) levels, are associated with gestational diabetes mellitus (GDM), according to a study published in the July 1 issue of the Journal of Clinical Endocrinology & Metabolism.

Shristi Rawal, Ph.D., from the National Institutes of Health in Bethesda, Md., and colleagues conducted a case-control study in which thyroid markers (fT3, fT4, and TSH) were measured and the fT3-to-fT4 ratio was derived across four visits in pregnancy. Trimester-specific associations of thyroid markers with subsequent GDM risk were examined after adjustment for thyroid autoimmunity status and major GDM risk factors. Participants included 107 GDM cases and 214 non-GDM controls from a multiracial pregnancy cohort.

The researchers found that both fT3 and fT3-to-fT4 ratio were positively correlated with GDM (adjusted odds ratios, 4.25 and 3.89 comparing the highest versus the lowest fT3 quartile at first and second trimester, respectively). At the first and second trimester, respectively, the corresponding risk estimates for fT3-to-fT4 ratio were 8.63 and 13.6. There were no significant associations for TSH or fT4 with GDM. In the second, but not the first, trimester, isolated hypothyroxinemia was significantly related to increased GDM risk (adjusted odds ratio, 2.97 comparing hypothyroxinemic with euthyroid women).

"Higher fT3 levels, potentially resulting from de novo synthesis or increased fT4 to fT3 conversion, may be an indicator of GDM starting early in pregnancy," the authors write.

Explore further: Thyroid dysfunction may lead to diabetes during pregnancy

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Thyroid dysfunction may lead to diabetes during pregnancy

June 7, 2018
Women with thyroid dysfunction in the first half of pregnancy face an increased risk for gestational diabetes, a form of diabetes that is typically diagnosed during the second trimester, according to a new study published ...

Anti-thyroid Rx exposure ups risk of congenital malformations

January 23, 2018
(HealthDay)—Exposure to anti-thyroid drugs (ATDs) during the first trimester of pregnancy is associated with increased risk of congenital malformations, according to a study published online Jan. 23 in the Annals of Internal ...

Unfavorable prepregnancy lipid levels linked to low parity

July 23, 2018
(HealthDay)—The risk of having no or only one child is elevated for women with an unfavorable prepregnancy lipid profile, according to a study published in the June issue of BMJ Open.

Thyroid cancer tied to regular thyroxine use in hypothyroidism

July 31, 2017
(HealthDay)—Patients with primary hypothyroidism who are regular thyroxine users have increased risk of thyroid cancer, according to a study published online July 19 in the Journal of Clinical Pharmacology.

Targeted thyroid testing not effective in pregnancy

June 19, 2014
(HealthDay)—A targeted thyroid testing approach is not effective during pregnancy in clinical practice, according to a study published online June 4 in Obstetrics & Gynecology.

Gestational diabetes may indicate future subclinical renal issues

May 10, 2018
(HealthDay)—Gestational diabetes mellitus (GDM) may be an early indicator of subsequent subclinical renal dysfunction, according to a study published online May 4 in Diabetes Care.

Recommended for you

Researchers have found that incidence of heart failure was around two-fold higher in people with diabetes

December 11, 2018
Researchers have found that incidence of heart failure was around two-fold higher in people with diabetes.

Millions of low-risk people with diabetes may be testing their blood sugar too often

December 10, 2018
For people with Type 2 diabetes, the task of testing their blood sugar with a fingertip prick and a drop of blood on a special strip of paper becomes part of everyday life.

Very low calorie diets trialled by NHS to tackle diabetes

December 7, 2018
Hundreds of thousands of people will receive NHS help to battle obesity and type 2 diabetes under radical action set out by Simon Stevens, Chief Executive of NHS England.

New therapeutic avenue for type 2 diabetes

December 6, 2018
Restoring the action of insulin is one of the keys to fighting type 2 diabetes. Researchers from Inserm led by Dominique Langin at the Institute of Cardiovascular and Metabolic Diseases (Inserm/Université de Toulouse) are ...

Subtype of immune B cells can delay type 1 diabetes onset in mice

December 6, 2018
A team of researchers at Baylor College of Medicine and the University of Michigan Medical School reports today in the JCI Insight that a subset of immune B cells, known as CD19+IgM+ B cells, can delay the onset of type 1 ...

Is the pancreas regeneration debate settled? An original theory renewed

December 5, 2018
A contentious debate among diabetes researchers has surrounded the regeneration of pancreatic insulin-producing cells: not if these cells regenerate, but rather how.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.