BPA exposure in U.S.-approved levels may alter insulin response in non-diabetic adults

September 14, 2018, University of Missouri-Columbia
3D chemical structure of bisphenol A. Credit: Edgar181 via Wikimedia Commons

In a first study of its kind study, researchers have found that a common chemical consumers are exposed to several times a day may be altering insulin release. Results of the study, led by scientists at the University of Missouri, indicate that the Food and Drug Administration-approved "safe" daily exposure amount of BPA may be enough to have implications for the development of Type 2 diabetes and other metabolic diseases.

"Bisphenol A is an endocrine disrupting chemical that is used to manufacture thermal paper receipts, plastics and a wide range of consumer products," said Frederick vom Saal, an endocrinologist and Curators' Professor in the Division of Biological Sciences in the MU College of Arts and Science, and a co-author on the study. "Experiments with human and mouse pancreatic cells have revealed that low-dose exposure to BPA, in the presence of glucose, triggers an insulin response. We wanted to test the potential effects of BPA in humans to see whether it held true."

In both of the studies, subjects were orally administered a safe dose of BPA, which led to the same amount of BPA in their blood that customers might encounter by handling a cash register receipt; or, the same subjects received a placebo exposure for comparison. Insulin responses were then assessed through an oral glucose tolerance test in the first experiment or a hyperglycemic clamp in the second experiment. Results of both studies showed that BPA altered relative to the placebo exposure in the subjects. In animal studies repeated BPA exposure resulted in insulin resistance.

"This exploratory study needs to be replicated because it suggests that BPA exposure at a dose considered safe by U.S. regulators could alter glucose-stimulated responses in humans," vom Saal said. "Our study is an initial step toward investigating whether to endocrine disrupting chemicals, such as BPA, contributes to and eventually Type 2 diabetes."

The study, "Experimental BPA Exposure and Glucose-Stimulated Insulin Response in Adult Men and Women," was published in the Journal of the Endocrine Society.

Explore further: Study characterizes insulin secretion in response to metabolic stress

More information: Richard W Stahlhut et al. Experimental BPA Exposure and Glucose-Stimulated Insulin Response in Adult Men and Women, Journal of the Endocrine Society (2018). DOI: 10.1210/js.2018-00151

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EyeNStein
not rated yet Sep 14, 2018
So how much BPA dose do you receive from a plastic lined can of soup, compared to dry handling a till reciept?

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