Brain iron on MRI linked to disability in multiple sclerosis

Brain iron on MRI linked to disability in multiple sclerosis

(HealthDay)—Brain iron at quantitative magnetic resonance imaging (MRI) is associated with disability in multiple sclerosis (MS), according to a study recently published in Radiology.

Robert Zivadinov, M.D., Ph.D., from the University at Buffalo in New York, and colleagues conducted a prospective study between March 2009 and November 2013 involving 600 participants with MS (452 with relapsing-remitting MS and 148 with secondary progressive MS) and 250 age- and sex-matched healthy controls. Magnetic was measured using 3.0-T MRI.

The researchers found that participants with MS presented with lower thalamic susceptibility (−7.5 versus −1.1 ppb) and higher susceptibility of (62 versus 54.8 ppb), compared with control participants. There was a correlation for lower thalamic susceptibility with longer disease duration, higher degree of disability, and secondary progressive course (β = −0.42, −0.64, and −4.3, respectively). There was a correlation for higher susceptibility of the globus pallidus with higher disability (β = 2). Lower thalamic susceptibility and higher susceptibility of the globus pallidus remained associated with clinical disability after correction for each individual structural volume in voxelwise analysis.

"In this large cohort of MS patients and healthy controls, we have reported, for the first time, increasing in the basal ganglia but decreasing in thalamic structures," Zivadinov said in a statement. "Iron depletion or increase in several structures of the brain is an independent predictor of disability related to MS."

Several authors disclosed financial ties to the pharmaceutical and medical device industries.

Explore further

Brain iron levels may predict multiple sclerosis disabilities

More information: Abstract/Full Text
Journal information: Radiology

Copyright © 2018 HealthDay. All rights reserved.

Citation: Brain iron on MRI linked to disability in multiple sclerosis (2018, September 25) retrieved 5 June 2020 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments