Berry juice processing by-products could reduce the risk of cancer

November 8, 2018, Kaunas University of Technology
Credit: Kaunas University of Technology (KTU)

Scientists at Kaunas University of Technology (KTU), Lithuania, are investigating the possibility of using berry pomace to increase the safety of meat products and to mitigate their negative effects on human health. According to the hypothesis proposed by the scientists, phytochemicals, i.e. the biologically active natural compounds found in berries, might mitigate the negative impact of additives used in meat products as well as naturally forming hazardous compounds during their processing, thus lowering the risk of cancer.

According to World Health Organization, consuming 50 g of processed a day (equivalent of two slices of bacon) increases the chance of developing colorectal cancer by 18 percent. WHO's International Agency for Research on Cancer classifies in the same category as tobacco smoking and asbestos (Group 1, carcinogenic to humans). Processed meat is meat that has been transformed through salting, curing, fermentation, smoking, or other processes to enhance flavour or to improve preservation.

"Nitrites and nitrates, used in meat products for increasing its taste and shelf-life can become carcinogenic nitrosamines in the process of digestion. Another type of carcinogenic substances form when meat is heated at very high temperature," says Professor Rimantas Venskutonis, chief researcher at the Food Science and Technology Department, KTU, Lithuania.

After several years of work on the subject, the scientists have collected great body of scientific evidence on the beneficial properties of bioactive ingredients found in berries – they are strong antioxidants, capable of subduing inflammatory processes in the organism, they can help diminish the risk of cardiovascular diseases and even destroy cancer cells.

"There is sufficient scientific evidence, both from our research and from that of our colleagues in other institutions, that some of the active substances found in berries could inhibit the process of carcinogenic substance formation in meat during heating. Moreover, once these substances are present in the body, they can activate certain defence mechanisms, detoxification systems, and in such a way, they might reduce the risk associated with the consumption of processed meat," says Prof Venskutonis.

The research project has two main goals. The first goal, according to Prof Venskutonis, is a technological one – to prove that substances extracted from pomace can be used in meat products as natural additives. As some of them are strong antioxidants, have antimicrobial properties and other useful properties, these naturally active ingredients can be used for increasing shelf-life of meat products, and improving their colour and other quality characteristics. The second, more complicated goal is to prove the actual benefits the phytochemicals have on . In order to step forward in this direction, the KTU researchers will collaborate with the Lithuanian University of Health Sciences.

At the moment, the first stage of the project, the bio-refining process during which bio-chemically active products from berry pomace are being recovered, is completed.

"We have scientific proof that berry-derived active substances can inhibit the growth of pathogenic bacteria and negative oxidation processes in meat products. Therefore, we can recommend using them instead of artificial additives in order to improve shelf life and quality of . However, in order to scientifically prove the potential health benefits of phytochemicals derived from berry pomace in diminishing the risk of cancer, more research needs to be done. We will take the first step in this direction by undertaking research with our colleagues from biomedical sciences and observing the impact phytochemicals have on cancer cells in vitro. This stage of the project will start shortly," says Prof Venskutonis.

Prof Venskutonis emphasises that the research group is using green chemistry methods in the bio-refinery process, during which several types of products are extracted from berry pomace. First, lipophilic substances are extracted. Then, using other solvents, polar substances containing the most antioxidants are obtained, and finally, during enzyme-assisted extraction, dietary fibre-rich ingredients are made. The process involves only environmentally friendly solvents such as water and ethanol, and methods such as supercritical carbon dioxide extraction.

"We are working with a zero-waste concept in mind – in our research, we are using berry pomace, which is a by-product of juice production usually discarded as waste. The bio-refining technology we developed allows us to berry pomace without any losses—their seed oil is of high value because it is rich in vitamin E, polyunsaturated fatty acids and other valuable compounds, while the beneficial effects of natural antioxidants and dietary fibre on human health is proven by many studies. Many of these functional ingredients can be used in food, cosmetics and even pharmaceutic industry," says Prof Venskutonis.

In the research, the pomace of mostly locally grown berries is being used. Some of the berries, such as raspberries, blueberries, cranberries and black chokeberries, are more common, and some, such as snowball tree berries, are less widely consumed and therefore under-investigated.

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