Expression of a molecule in blood cells predicts atherosclerosis risk

Expression of a molecule in blood cells predicts atherosclerosis risk
The main study authors: Pilar Marín, Hortensia de la Fuente, and Francisco Sánchez-Madrid. Credit: CNIC

Earlier detection of cardiovascular disease is a step closer thanks to the findings of a research team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) led by Francisco Sánchez-Madrid and Pilar Martín. The scientists found that the expression level of the molecule CD69 in blood cells inversely predicts the appearance of subclinical atherosclerosis (developing before symptoms appear) independently of classical cardiovascular risk factors.

Atherosclerosis is a disease characterized by the accumulation of lipid deposits in the artery wall, but the disease is usually not detected until after it has caused a clinical event such as a myocardial infarction or stroke. Because of the diminished quality of life experienced by affected individuals, treatment after symptoms appear is of limited benefit, and the long-term management of the disease is a major cost for health care systems.

The origin of atherosclerosis and its progression to acute myocardial infarction and stroke involve an essential contribution from the inflammatory immune response. However, according to Francisco Sánchez-Madrid, of the Hospital Universitario de la Princesa (Madrid), "the relationship between lipid metabolism and the immune response is not well understood. The established hypothesis is that oxidized low-density lipoproteins (LDLox) induce the recruitment of inflammatory immune cells and their accumulation in the plaque; however, there is also evidence that cells and tissues can respond to LDLox by inhibiting proinflammatory signals."

The study was a collaboration between the CNIC research groups led by Sánchez-Madrid and Pilar Martín. The study identifies the molecule CD69 as a T cell receptor for oxidized lipoproteins that contributes to the control of inflammation and thus prevents the development of atherosclerosis. "Binding of LDLox to CD69 triggers the adoption of an anti-inflammatory profile by T lymphocytes that protects against the development of atherosclerosis in mice and humans," explained Pilar Martín. For this , the team used mice lacking the CD69 gene. The project was supported by the Spanish Cardiovascular Disease Research Network (CIBER-CV) as was conducted in partnership with José Martínez González, whose group is based at the Instituto de Investigaciones Biomédicas in Barcelona (IIB-Sant Pau).

The clinical relevance of the study is demonstrated by the results of an analysis of lymphocyte-expressed CD69 in obtained from 305 participants in the PESA project (Progression of Early Subclinical Atherosclerosis). PESA is a prospective study that uses advanced imaging techniques to detect the presence of atherosclerotic plaques in overtly healthy individuals. This part of the study was conducted in partnership with the PESA project investigators Valentín Fuster and Borja Ibáñez and the CNIC technical units focused on Bioinformatics (Fátima Sánchez-Cabo), Genomics (Ana Dopazo), and Proteomics (Jesús Vázquez). The PESA study is a joint project between the CNIC and Banco Santander and is led by Dr. Fuster. The study evaluates the presence and progression of atherosclerosis in more than 4000 middle aged participants.

The results of the Circulation study show that the expression of CD69 in circulating lymphocytes correlates inversely with the presence and extent of subclinical atherosclerosis. Cardiovascular disease is the single largest cause of death in the world, and preventive strategies for this disease are therefore a major priority.


Explore further

Scientists identify an essential role of the immune receptor CD69 in psoriasis

More information: Katerina Tsilingiri et al, Oxidized Low-Density Lipoprotein Receptor in Lymphocytes Prevents Atherosclerosis and Predicts Subclinical Disease, Circulation (2019). DOI: 10.1161/CIRCULATIONAHA.118.034326
Journal information: Circulation

Provided by Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)
Citation: Expression of a molecule in blood cells predicts atherosclerosis risk (2019, January 11) retrieved 24 June 2019 from https://medicalxpress.com/news/2019-01-molecule-blood-cells-atherosclerosis.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more