Designing antibodies to fight the flu

Designing antibodies to fight the flu
Credit: AI-generated image (disclaimer)

The influenza virus is an annual threat to public health around the world. Rapid changes in viral surface proteins (antigens), however, make it difficult to identify antibodies with broadly neutralizing activity against different influenza subtypes.

Reporting in the Proceedings of the National Academy of Sciences, James Crowe Jr., MD, Jens Meiler, Ph.D., and colleagues describe how they developed and applied a to redesign an anti-influenza antibody, C05, against a large panel of up to 500 seasonal antigens of the H1 influenza subtype.

The redesigned had an approximately fivefold increased affinity against one strain of influenza and a now detectable binding to another strain while maintaining high-affinity binding to previously targeted antigens in the panel.

The researchers said their work shows that computational design can improve the ability of naturally occurring antibodies to recognize different viral strains. C05, for example, is a clinically relevant antibody that could hasten development of more effective flu therapies and vaccines, they concluded.

Citation: Designing antibodies to fight the flu (2019, February 1) retrieved 3 March 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Anti-flu antibodies can inhibit two different viral proteins, study reveals


Feedback to editors