Birch pollen allergen immunotherapy normalizes nasal gene-expression and microbial community

birch tree
Credit: CC0 Public Domain

Birch pollen allergic rhinitis is the most common chronic disorder in the Northern part of the globe, and it attributes to significant morbidity and economic burden.

According to the new study by researchers at the University of Helsinki, pollen allergen immunotherapy has favorable effects on the molecular events and microbiome profile in the nasal membrane.

The researchers studied five healthy, nonsmoking adult subjects and six allergic rhinitis patients longitudinally during two springs and two winters in 2011 and 2012. Half of the allergy patients started subcutaneous birch allergen immunotherapy after the first winter.

In total, 44 nasal brushings were subjected to RNA-sequencing analysis to find and microbial community changes driven by and allergen immunotherapy.

According to the results, the group who started allergen immunotherapy showed decreased symptom score and reprogramming of nasal epithelial transcriptome, set of RNA molecules, during the pollen season.

"The immunotherapy affected asthma-, chemokine signaling-, and toll-like-receptor-signaling-pathways in the spring. No major differential expression was found between the two winters in any group," says researcher Sanna Toppila-Salmi from the University of Helsinki and Helsinki University Hospital.

The results also indicated that microbial community diversity of the group that underwent allergen immunotherapy approached that of the healthy controls.

According to the researchers, the study shows that RNA sequencing is a promising method to monitor allergen immunotherapy response.


Explore further

Shorter course of immunotherapy does not improve symptoms of allergic rhinitis long-term

More information: Tanzeela Hanif et al. Birch pollen allergen immunotherapy reprograms nasal epithelial transcriptome and recovers microbial diversity, Journal of Allergy and Clinical Immunology (2019). DOI: 10.1016/j.jaci.2019.02.002
Citation: Birch pollen allergen immunotherapy normalizes nasal gene-expression and microbial community (2019, February 19) retrieved 22 July 2019 from https://medicalxpress.com/news/2019-02-birch-pollen-allergen-immunotherapy-nasal.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
20 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more