Oily formulations for efficient oral medications

Oily formulations for efficient oral medications
Hayley hopes the new formulation can improve oral medication. Credit: University of South Australia Cancer Research Institute

A new recipe for pills and tablets that includes oils and tiny porous particles can help your body absorb medicines more than twice as effectively.

"Around 40 per cent of drugs on the market are poorly soluble in water, and they are not being administered efficiently," says Hayley Schultz, the University of South Australia researcher who has developed the new formulation.

"When poorly water-soluble drugs enter the gut, they don't dissolve very well. This means only a small portion of the drug can be absorbed across the gut wall into the bloodstream where it can have its ."

The Adelaide scientist has developed an oil-based formulation that mimics the food effect to improve the of such drugs.

"These drugs are often taken without food, as the oil and fat content results in increased and unpredictable drug absorption. My new formulation mimics this phenomenon by incorporating oils to achieve greater absorption in a predictable way," Hayley says.

"The formulation also contains tiny particles of porous silica. These are like sponges, full of tiny holes we can fill up with the and oil to form a stable powdered formulation. The powder can then be filled into a capsule or pressed into a tablet for easy oral administration."

Hayley has demonstrated that the formulation results in more than twice the oral absorption of ibuprofen—by 220 per cent when compared to the commercial product Nurofen.

"I look forward to applying the formulation to other poorly water-soluble drugs —including one for —to improve their absorption and to develop more efficient medications with lower doses."


Explore further

Sustainability-driven developments in a transplant rejection drug's formulation

Provided by University of South Australia
Citation: Oily formulations for efficient oral medications (2019, February 13) retrieved 20 March 2019 from https://medicalxpress.com/news/2019-02-oily-efficient-oral-medications.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more