Probing H. pylori cancer protein

Infection with the stomach-dwelling bacterium Helicobacter pylori— particularly strains producing the oncoprotein CagA—is a strong risk factor for gastric cancer.

Previous studies found that a region called the +59 motif in the transcript for CagA (the RNA "copy" of the gene that includes the template for ) is associated with high levels of CagA protein and premalignant disease.

Now, Timothy Cover, MD, John Loh, Ph.D., and colleagues have explored how the +59 motif and a nearby stem-loop structure affect CagA gene expression. They found that mutations that disrupt the stem-loop structure reduced levels of the transcript and protein by decreasing the stability of the mRNA. Mutations that altered the +59 motif also reduced transcript and protein levels, but did not impact mRNA stability.

The , reported in the February issue of Infection and Immunity, point to determinants of CagA gene expression and improve understanding of a factor that influences the risk of premalignant and malignant changes in the stomach.

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More information: John T. Loh et al. Role of a Stem-Loop Structure in Helicobacter pylori cagA Transcript Stability, Infection and Immunity (2018). DOI: 10.1128/IAI.00692-18
Journal information: Infection and Immunity

Citation: Probing H. pylori cancer protein (2019, February 18) retrieved 16 January 2022 from
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