Promising esophageal reconstruction based on engineered constructs

Promising esophageal reconstruction based on engineered constructs
Credit: (c) 2019 Mary Ann Liebert, Inc., publishers

The loss of complete segments of the esophagus often results from treatments for esophageal cancer or congenital abnormalities, and current methods to re-establish continuity are inadequate. Now, working with a rat model, researchers have developed a promising reconstruction method based on the use of 3-D-printed esophageal grafts. Their work is published in Tissue Engineering.

Eun-Jae Chung, MD, Ph.D., Seoul National University Hospital, Korea, Jung-Woog Shin, Ph.D., Inje University, Korea, and colleagues present their research in an article titled "Tissue-Engineered Esophagus via Bioreactor Cultivation for Circumferential Esophageal Reconstruction". The authors created a two-layered tubular scaffold with an electrospun nanofiber inner layer and 3-D-printed strands in the outer layer. After seeding human mesenchymal stem cells on the inner layer, constructs were cultured in a bioreactor, and a new surgical technique was used for implantation, including the placement of a thyroid gland flap over the scaffold. Efficacy was compared with omentum-cultured scaffolding technology, and successful implantation and esophageal reconstruction were achieved based on several metrics.

"Dr. Chung and colleagues from Korea present an exciting approach for esophageal repair using a combined 3-D printing and bioreactor cultivation strategy," says Tissue Engineering Co-Editor-in-Chief John P. Fisher, Ph.D., Fischell Family Distinguished Professor & Department Chair, and Director of the NIH Center for Engineering Complex Tissues at the University of Maryland. "Critically, their work shows integration of the engineered esophageal tissue with host , indicating a clinically viable strategy for circumferential esophageal ."


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More information: In Gul Kim et al. Tissue-Engineered Esophagus via Bioreactor Cultivation for Circumferential Esophageal Reconstruction, Tissue Engineering Part A (2019). DOI: 10.1089/ten.tea.2018.0277
Citation: Promising esophageal reconstruction based on engineered constructs (2019, June 18) retrieved 22 August 2019 from https://medicalxpress.com/news/2019-06-esophageal-reconstruction-based.html
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