Study explores dose ranges for efpeglenatide in early T2DM

Study explores dose ranges for efpeglenatide in early T2DM

(HealthDay)—Efpeglenatide once weekly leads to dose-dependent reductions in glucose and body weight in patients with early type 2 diabetes, according to a phase 2 study published online July 18 in Diabetes Care.

Julio Rosenstock, M.D., from the Dallas Diabetes Research Center at Medical City, and colleagues evaluated the safety and efficacy of once-weekly efpeglenatide, a long-acting glucagon-like peptide 1 receptor agonist (GLP-1 RA), in early type 2 diabetes (drug naive or on metformin monotherapy [90 percent]). Among the participants, 181 were randomly assigned to one of five efpeglenatide doses (0.3, 1, 2, 3, or 4 mg q.w.), 37 received a , and 36 received liraglutide (≤1.8 mg daily).

The researchers found that during the 12-week study period, all efpeglenatide doses ≥1 mg significantly reduced HbA1c versus placebo to a final HbA1c of 6.3 to 6.8 percent versus 7.7 to 8 percent at baseline. Masked efpeglenatide 4 mg was noninferior to open-label liraglutide. Compared with placebo, greater proportions treated with efpeglenatide ≥1 mg achieved HbA1c <7 percent (61 to 72 percent versus 24 percent). There were also greater reductions in with efpeglenatide 3 and 4 mg versus placebo. After the initial two weeks, reports of nausea and vomiting subsided.

"Efpeglenatide once weekly led to significant reductions in HbA1c and weight, with a safety profile consistent with the GLP-1 RA class in patients with early type 2 mostly on metformin monotherapy," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Sanofi, which manufactures efpeglenatide and funded the study.


Explore further

Oral semaglutide reduces HbA1c, weight in patients with T2DM

More information: Abstract/Full Text (subscription or payment may be required)
Journal information: Diabetes Care

Copyright © 2019 HealthDay. All rights reserved.

Citation: Study explores dose ranges for efpeglenatide in early T2DM (2019, August 5) retrieved 19 August 2019 from https://medicalxpress.com/news/2019-08-explores-dose-ranges-efpeglenatide-early.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
2 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more