Bionic pacemaker slows progression of heart failure

Bionic pacemaker slows progression of heart failure
Credit: University of Bristol

Using brain circuits made in silicon, scientists have alleviated symptoms of heart failure by reinstating the body's natural heart rhythm. This study published in The Journal of Physiology today holds great potential for designing more effective pacemakers in the future.

In the UK alone, around 900,000 people are living with heart failure and almost 1.4 million have survived a . After such an event, pacemakers are often fitted to either speed up the heart or to overcome electrical conduction problems between different chambers of the heart. There is no cure for heart failure; its progression is only slowed by current medication.

The heartbeat is never constant; it varies with every breath. It speeds up when you inhale and slows down when you exhale. This difference in heart rate is known as respiratory sinus arrhythmia. Researchers at the Universities of Bath and Bristol have adopted this arrhythmia in a novel bionic pacemaker and applied it to a heart in heart failure. They found that this new form of heart pacing dramatically increases the efficiency of the heart.

Normally, pacemakers don't listen to signals from our bodies; they simply pace the heart at a monotonous, regular rate. These researchers, however, built a that read the body's own breathing signals to speed up and slow down the heart every breath.

Dr. Erin O'Callaghan, lead author of the study, said: "We used state-of-the-art high-resolution echocardiography to monitor the heart's performance during respiratory sinus arrhythmia pacing in rats with heart failure. Within two weeks there was a 20 percent increase in blood pumped by the heart which was not the case when we used conventional pacemakers."

Dr. Ed Duncan, consultant cardiologist from the Bristol Heart Institute, added: "We are very excited by this large response. This approach may represent a novel therapy in addition to those already available for the treatment of heart failure."

Julian Paton, Professorial Research Fellow in Physiology, School of Physiology, Pharmacology and Neuroscience at the University of Bristol, and senior author on the study, remarked: "Our findings give hope for failure patients and may revolutionize the future design of cardiac pacemakers. Our next step in the research is to find out if respiratory sinus arrhythmia can reverse in human patients, as it has done in rats."

More information: Erin L O'Callaghan et al. Enhancing respiratory sinus arrhythmia increases cardiac output in rats with left ventricular dysfunction, The Journal of Physiology (2019). DOI: 10.1113/JP277293
Journal information: Journal of Physiology

Citation: Bionic pacemaker slows progression of heart failure (2019, November 13) retrieved 6 December 2022 from
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