Flu shot can provide effective immunity for people living with HIV

influenza
Influenza viruses, like the model shown here, display several kinds of surface proteins on their exteriors. Credit: NIAID

People who are being treated for HIV can gain effective protection against seasonal flu with the influenza (flu) vaccine, new findings confirm.

Since people living with HIV can have an impaired and may be at higher risk of serious illness from flu, they are recommended to get the seasonal influenza every year.

However, prior to the new study it was unclear how well the vaccine protected people with HIV taking (ART) – the gold standard treatment which reduces the virus to undetectable levels.

Dr. Katrina Pollock, from the Department of Infectious Disease at Imperial, led a team which found that the flu vaccine triggered effective immune responses in people living with HIV who were taking ART and in whom HIV was fully suppressed.

Their findings are published in the journal Scientific Reports.

"The current recommendation is for people at risk of serious illness from flu, including people living with HIV, to receive a vaccine containing four influenza strains to protect them from seasonal flu," said Dr. Pollock.

"Some studies indicate that vaccine-induced immunity may be impaired in people living with HIV. There has been a lack of data showing whether effective HIV suppression with modern antiretroviral therapy can fully restore vaccine-induced immunity.

"Our study shows equivalent flu vaccine responses in people living with HIV and in healthcare workers, and indicates that restoration of vaccine-induced immunity is possible. This supports universal access to antiretroviral therapy for people who test positive for HIV and provides evidence underpinning the guidance for vaccination in people living with HIV."

Seasonal protection

In the UK, the British HIV Association recommends that people living with HIV should be offered a vaccine containing four different types of flu virus—a quadrivalent vaccine of two A-strains and two B-strains.

The study, known briefly as the FluAGE study compared responses to this four-strain vaccine amongst men with HIV taking ART with those of during the winter of 2017-18.

The team studied the immune responses that help protect from flu and pinpointed exactly the types of cells that were responding.

They found that the was very similar in the people with fully suppressed HIV on ART and the control subjects. Using a method developed at Public Health England with Dr. Katja Hoschler, gum-line samples, which were collected by participants themselves, were used to show that responses could be measured from the mouth as a potential alternative to blood testing.

Ms Megan Cole, first author on the study, also from the Department of Infectious Disease, said: "It's been exciting to be part of this research and to conclude it with the positive outcome in terms of the restoration of vaccine-induced immunity in people living with HIV. This is why I find science so rewarding. Thank you to the team and participants who have made this study a success."


Explore further

Only thing certain about flu season: you need to get your shot

More information: Megan E. Cole et al. Responses to Quadrivalent Influenza Vaccine Reveal Distinct Circulating CD4+CXCR5+ T Cell Subsets in Men Living with HIV, Scientific Reports (2019). DOI: 10.1038/s41598-019-51961-9
Journal information: Scientific Reports

Citation: Flu shot can provide effective immunity for people living with HIV (2019, November 7) retrieved 12 November 2019 from https://medicalxpress.com/news/2019-11-flu-shot-effective-immunity-people.html
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