Brush cells in the nose found to secrete proinflammatory lipids

Brush cells in the nose found to secrete proinflammatory lipids
Nasal septum tissue of a mouse (middle). Brush cells (green) were rare in the nasal respiratory epithelium (right), and highly concentrated in the main olfactory epithelium (left). Credit: Ualiyeva et al., Sci. Immunol. 5, eaax7224 (2020)

A team of researchers working at Brigham and Women's Hospital and Harvard Medical School has found evidence of brush cells in the mouse nose secreting proinflammatory lipids. In their paper published in the journal Science Immunology, the group describes their study of chemical-sensing cells in the noses of mice and what they learned about them.

Human allergies and sensitivities to environmental materials have grown worse over the past several centuries as human activities have resulted in an increase in irritants. Scientists studying allergies have learned a lot about what happens during such reactions, but still do not know what triggers them. In this new effort, the researchers working in Boston have found evidence of chemical-sensing in the noses of that produce chemicals that lead to inflammation.

As part of an effort to learn more about the that cause inflammatory reactions to irritants, the researchers studied chemical-sensing brush cells inside the noses and along the respiratory tracts of mice. To learn more about the cells, the researchers exposed them to a variety of known irritants and observed the responses.

Prior research has shown that in the blood produce a lipid known as cysteinyl leukotriene. This fatty acid has been identified as playing a role in allergic and sensitivity reactions. Careful study of the mouse nasal brush cells showed that they, too, produce the lipid—but only when exposed to certain molds or dust mite proteins, or the energy carrier adenosine triphosphate. Testing the cells in living mice showed that exposure to the same irritants produced swelling in nasal tissue. The researchers also found that if they removed the brush cells from the noses of test mice, they experienced less inflammation.

Brush cells in the nose found to secrete proinflammatory lipids
Brush cells (green) in nasal septum found in the olfactory epithelium (top row) and respiratory epithelium (bottom row). They expressed various molecules typical of the taste cell family, including DCLK1 (red), confirming their identity as brush cells. Credit: Ualiyeva et al., Sci. Immunol. 5, eaax7224 (2020)

The researchers next plan to carry out similar research on brush cells in humans. If they find similar results, the next step will be to study the possibility of turning off their response to irritants or removing them altogether in extreme cases. They also plan to continue their study of brush cells as part of their effort to learn more about the factors that lead people to develop allergies.

Brush cells in the nose found to secrete proinflammatory lipids
Cross-section of the nasal cavity (left) and brush cells (in green and light blue) found in the olfactory epithelium (top right) and respiratory epithelium (bottom right). Credit: Ualiyeva et al., Sci. Immunol. 5, eaax7224 (2020)

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Journal information: Science Immunology

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