New therapy may ease congestion for heart failure patients

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The American Heart Association estimates that the total cost of heart failure in the United States could reach $70 billion by 2030. Volume overload contributes to 90% of heart failure-related hospitalizations in the U.S. A new therapy developed by Sequana Medical demonstrates that direct sodium removal (DSR) is a safer alternative to remove excess sodium from the body.

The research, led by Jeffrey Testani, MD, Director of Heart Failure research at Yale Cardiovascular Medicine, shows that DSR produced greater sodium removal than a standard peritoneal dialysis solution.

During the study, patients with either received a dose of DSR solution or standard therapy. The DSR technique removed over four-times the amount of sodium than the strongest commercially available solution. The patients who received DSR did not experience any significant discomfort or toxic side effects that are common in standard methods.

In a January 10 press release Dr. Testani said, "Volume overload is the primary driver of morbidity and hospitalization in patients with heart failure and loop diuretics, the mainstay of therapy, have well recognized toxicities and loss of response is common. DSR represents a new potential therapy for non-renal sodium and fluid removal in edematous disorders such as ."

Currently, additional is underway to test the safety and efficacy of this therapy when combined with other therapies.

The study is published in Circulation.

More information: Veena S. Rao et al. First in Human Experience with Peritoneal Direct Sodium Removal Using a Zero Sodium Solution: A New Candidate Therapy for Volume Overload, Circulation (2020). DOI: 10.1161/CIRCULATIONAHA.119.043062

Journal information: Circulation

Provided by Yale University
Citation: New therapy may ease congestion for heart failure patients (2020, January 30) retrieved 29 January 2023 from
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