Birth timing may affect brain development

Birth timing may affect brain development
Advancing birth triggers cell death, but delaying birth does not affect timing of cell death. Credit: Castillo-Ruiz et al., eNeuro 2020

Moving birth a day early triggers an early start to widespread neuron death, according to new research in mice published in eNeuro.

Right before and after birth, about half of the neurons in the developing brain die. Scientists have known about this normal process for half a century, but no one knows what controls it. Is it an external signal like birth, or an innate developmental mechanism?

Castillo-Ruiz et al. induced labor a day early or pushed birth a day late in mice—still within the healthy time frame- and monitored how the change affected neuron death. By focusing on that experience extreme soon after birth, the researchers could detect the effects of small changes in birth timing.

Early birth prompted cell death to start a day early but delaying birth did not alter when cell occurred. This indicates that a developmental process takes over when is delayed. The results raise questions about the consequences for subsequent brain development when women opt to induce labor early.

More information: Does Birth Trigger Cell Death in the Developing Brain? eNeuro DOI: 10.1523/ENEURO.0517-19.2020

Citation: Birth timing may affect brain development (2020, February 3) retrieved 23 February 2024 from
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