Mortality no different for no sedation versus light sedation in ICU patients

Mortality no different for no sedation versus light sedation in ICU patients

(HealthDay)—For mechanically ventilated intensive care unit (ICU) patients, mortality at 90 days is no different for those randomly assigned to no sedation and those assigned to light sedation with daily interruption, according to a study published online Feb. 16 in the New England Journal of Medicine to coincide with the Society of Critical Care Medicine annual Critical Care Congress, held from Feb. 16 to 19 in Orlando, Florida.

Hanne T. Olsen, M.D., from Odense University Hospital-Svendborg Hospital in Denmark, and colleagues conducted a multicenter randomized trial involving 700 mechanically ventilated ICU patients. Participants were randomly assigned to either a plan of no sedation (nonsedation group) or a plan of light sedation (sedation group) with daily interruption.

The researchers found that the mean Richmond Agitation and Sedation Scale score increased from −1.3 on day 1 to −0.8 on day 7 in the nonsedation group and from −2.3 on day 1 to −1.8 on day 7 in the sedation group. At 90 days, mortality was 42.4 and 37.0 percent in the nonsedation and sedation groups, respectively (difference, 5.4 percentage points; 95 percent confidence interval, −2.2 to 12.2; P = 0.65). There was no noted between the trial groups in the number of ICU-free days or ventilator-free days. Participants in the nonsedation and sedation groups had a median of 27 and 26 days free from coma or delirium, respectively.

"The plan of no resulted in no important differences in the number of ventilator-free days or in the length of ICU or hospital stay," the authors write.


Explore further

Many nurses believe in sedation for comfort of ventilated patients

More information: Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Journal information: New England Journal of Medicine

Copyright © 2020 HealthDay. All rights reserved.

Citation: Mortality no different for no sedation versus light sedation in ICU patients (2020, February 18) retrieved 28 November 2020 from https://medicalxpress.com/news/2020-02-mortality-sedation-icu-patients.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors

User comments