Clinical trial begins for new COVID-19 treatment

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The University of Rochester Medical Center (URMC) is participating in a NIH-sponsored clinical trial to evaluate the safety and efficacy of the investigational antiviral drug remdesivir in hospitalized adults diagnosed with COVID-19. The study is being led by Ann R. Falsey, M.D., and Angela R. Branche, M.D., with the URMC Vaccine Trials and Evaluation Unit (VTEU).

Remdesivir, developed by Gilead Sciences, is a broad-spectrum antiviral treatment that has been previously tested in humans with the Ebola virus and has shown promise in animal models for treating Middle East respiratory syndrome (MERS) and (SARS), which are caused by other coronaviruses. It is believed that the drug blocks a particular enzyme that is required for viral replication.

The double-blind, placebo-controlled trial will involve acute COVID-19 inpatients at Strong Memorial Hospital. The study may be expanded over time to include additional investigational antiviral treatments.

The URMC VTEU was established with support from the National Institute of Allergy and Infectious Diseases to conduct of vaccines, treatments, and diagnostics for known and emergent infectious threats. URMC is one of only nine VTEU sites in the U.S.

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Citation: Clinical trial begins for new COVID-19 treatment (2020, April 1) retrieved 10 August 2022 from
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