Trial questions benefits of organic nitrates for bone health

bone
Credit: CC0 Public Domain

Several clinical trials have reported beneficial effects of organic nitrates on bone health, which could lead to a reduced risk of fractures. Some of these trials have been retracted because of scientific misconduct; however. A new study published in the Journal of Bone and Mineral Research found that organic nitrates do not have clinically relevant effects on bone mineral density or bone turnover in postmenopausal women, and the medications caused significant side effects.

The study was a double-blind, randomized, placebo-controlled trial of three different nitrate preparations and two different doses in with . There were no differences in changes in bone mineral density or bone turnover markers between organic nitrate treatment and placebo.

The results call into question the validity of previous clinical research reporting large positive effects of nitrates on .

"Based on previous , we had high hopes that treatment with nitrates might be a safe and highly effective treatment for preventing age-related bone loss and fractures. We assessed several different doses and forms of nitrates and our results show clearly that no preparation or dose had any effect on bone density or bone turnover, but they did cause significant side-effects for women," said lead author Mark Bolland, MBChB, Ph.D., of the University of Auckland, in New Zealand. "Sadly, this research area has recently had several studies with strongly positive results retracted because of scientific misconduct. We think our paper provides closure, with fairly definitive evidence that nitrates do not affect surrogate measures of bone health and thus there is no reason to think they would prevent fractures."


Explore further

Blood marker may predict postmenopausal women's risk of bone fractures

More information: Mark J Bolland et al, Nitrates Do Not Affect Bone Density or Bone Turnover in Postmenopausal Women: A Randomized Controlled Trial, Journal of Bone and Mineral Research (2020). DOI: 10.1002/jbmr.3982
Provided by Wiley
Citation: Trial questions benefits of organic nitrates for bone health (2020, May 6) retrieved 6 July 2020 from https://medicalxpress.com/news/2020-05-trial-benefits-nitrates-bone-health.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
0 shares

Feedback to editors

User comments