Ancestral lineage of tuberculosis discovered in the African Great Lakes region

tuberculosis
Credit: CC0 Public Domain

Two exceptional strains of tuberculosis, isolated from East African patients with multi-resistant forms of the disease, have been discovered thanks to the use of a new molecular test, Deeplex-MycTB.

These belong to a so far unknown bacterial lineage, apparently limited to the African Great Lakes region.

Genome analyzes show that this lineage originated from an ancestral phylum which predates the branching point shared by all other lineages of common strains known to date.

This discovery reinforces the hypothesis of an East African origin for the tuberculosis bacillus, which remains the main cause of death from infectious causes, and provides additional molecular clues about the evolution towards a pathogenic lifestyle.

This work, carried out by an international team led by researchers from the Lille Centre for Infection and Immunity (CNRS/Inserm/Institut Pasteur de Lille/Université de Lille/CHU de Lille), is published on June 9th 2020 in Nature Communications.


Explore further

Influenza: Combating bacterial superinfection with the help of the microbiota

More information: A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region. Nature Communications (2020). DOI: 10.1038/s41467-020-16626-6
Journal information: Nature Communications

Provided by CNRS
Citation: Ancestral lineage of tuberculosis discovered in the African Great Lakes region (2020, June 9) retrieved 4 March 2021 from https://medicalxpress.com/news/2020-06-ancestral-lineage-tuberculosis-african-great.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
2 shares

Feedback to editors

User comments