Type 2 diabetes may negatively impact bone density in youth

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Type 2 diabetes may negatively impact bone density around the age of peak bone mass, according to a study published online Aug. 10 in Diabetes Care.

Joseph M. Kindler, from the Children's Hospital of Philadelphia, and colleagues compared in youth with type 2 diabetes to control patients with obesity or healthy weight. The included youth (56 percent African American; 67 percent female) ages 10 to 23 years with type 2 diabetes (180 patients), obesity (body mass index [BMI] >95th; 226 patients), or healthy weight (BMI <85th; 238 patients).

The researchers observed age-dependent differences in areal bone mineral density (aBMD) and lean BMI z scores between the three groups. In children, aBMD and lean BMI z scores were greater in the type 2 diabetes group versus the obese group, while among adolescents and young adults, aBMD and lean BMI z scores were lower in the type 2 diabetes group versus the obese group. aBMD was approximately 0.5 standard deviations lower for a given lean BMI z score in the type 2 diabetes group and the obese group versus healthy-weight control patients. aBMD also was lower in those with greater visceral fat.

"Results from this study suggest that type 2 in youth may have a detrimental effect on bone accrual during the critical window of peak bone mass attainment irrespective of obesity status," the authors write.


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More information: Joseph M. Kindler et al. Bone Mass and Density in Youth With Type 2 Diabetes, Obesity, and Healthy Weight, Diabetes Care (2020). DOI: 10.2337/dc19-2164
Journal information: Diabetes Care

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