Recent diabetes and weight loss tied to pancreatic cancer risk

Recent diabetes + weight loss tied to pancreatic cancer risk

(HealthDay)—Recent-onset diabetes accompanied by weight loss is associated with a substantially increased risk for developing pancreatic cancer, according to a study published online Aug. 13 in JAMA Oncology.

Chen Yuan, Sc.D., from Dana-Farber Cancer Institute in Boston, and colleagues used data from 112,818 women participating in the Nurses' Health Study and 46,207 men participating in the Health Professionals Follow-Up Study to evaluate the association of duration and recent weight change with the subsequent risk for pancreatic cancer.

The researchers identified 1,116 incident cases of pancreatic cancer. Participants with recent-onset diabetes had a higher age-adjusted risk for pancreatic cancer (hazard ratio [HR], 2.97), as did those with long-standing diabetes (HR, 2.16), compared with participants without diabetes. Participants who reported 1 to 4 pounds of weight loss had a higher age-adjusted risk for pancreatic cancer (HR, 1.25), as did those with 5 to 8 pounds of weight loss (HR, 1.33) and those with more than an 8-pound weight loss (HR, 1.92) compared with those with no weight loss. Participants with recent-onset diabetes plus weight loss of 1 to 8 pounds had still higher risk (HR, 3.61), as did those with more than 8 pounds of loss (HR, 6.75) compared with those with neither exposure.

"Individuals with recent-onset diabetes accompanied by have a high risk for developing and may be a group for whom early detection strategies would be advantageous," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

More information: Abstract/Full Text (subscription or payment may be required)

Journal information: JAMA Oncology

Copyright © 2020 HealthDay. All rights reserved.

Citation: Recent diabetes and weight loss tied to pancreatic cancer risk (2020, August 18) retrieved 2 March 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Diabetes may be an early manifestation of pancreatic cancer


Feedback to editors