Researchers find new measure to predict stress resilience

Researchers find new measure to predict stress resilience
Fig. 1: Experimental task and neural conflict-induced upregulation responses (CI > II). Credit: Nature Communications (2021). DOI: 10.1038/s41467-021-22509-1

Researchers at the University of Zurich show that increased sensitivity in a specific region of the brain contributes to the development of anxiety and depression in response to real-life stress. Their study establishes an objective neurobiological measure for stress resilience in humans.

Some people don't seem to be too bothered when it comes to handling stress. For others, however, prolonged exposure to stress can lead to symptoms of anxiety and depression. While stress is a widely discussed concept, it is still very challenging to predict people's individual response to increased levels of stress. Lab experiments can only go so far in replicating the many people experience in their day-to-day lives, as stress simulated in the lab is always limited in exposure time and intensity.

It is possible, however, to observe a group of medical students who are all about to face real-life stress for an extended period—during their six-month internship in the emergency room. This is precisely the real-life situation on which a team of researchers involving Marcus Grueschow and Christian Ruff from the UZH Zurich Center for Neuroeconomics and Birgit Kleim from the Department of Psychology and the University Hospital of Psychiatry Zurich based their study.

Stress as a response to cognitive conflict and loss of control

Before starting their internship, the subjects were given a task that required them to process conflicting information. This conflict task activates the locus coeruleus-norepinephrine (LC-NE) system, a region of the brain associated with regulating our response to stress and resolving conflict. However, the intensity of LC-NE activation—often referred to as the "firing rate"—varies from one person to the next.

Subjects with a higher LC-NE responsivity showed more symptoms of anxiety and depression following their emergency room internships. "The more responsive the LC-NE system, the more likely a person will develop symptoms of anxiety and depression when they're exposed to prolonged stress," Marcus Grueschow summarizes their findings.

Objective measure predicting stress resilience

With their study, the scientists have identified an objective neurobiological measure that can predict a person's stress response. This is the first demonstration that in humans, differences in LC-NE responsivity can be used as an indicator for stress resilience. "Having an objective measure of a person's ability to cope with stress can be very helpful, for example when it comes to choosing a profession. Or it could be applied in stress resilience training with neuro-feedback," Marcus Grueschow explains.

This does not mean that aspiring doctors or future police officers will all have to have their brain scanned. "There might be an even more accessible indicator for resilience," Christian Ruff says. Research with animals suggests that stimulation of the LC-NE system correlates with pupil dilation. "If we could establish the same between pupil dilation and the LC-NE system in humans, it would open up another avenue," he adds.

The research is published in Nature Communications.

More information: Marcus Grueschow et al. Real-world stress resilience is associated with the responsivity of the locus coeruleus, Nature Communications (2021). DOI: 10.1038/s41467-021-22509-1

Journal information: Nature Communications
Citation: Researchers find new measure to predict stress resilience (2021, April 15) retrieved 27 May 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Study examines ADHD symptoms, stress, and resilience in college students


Feedback to editors