Erythropoietin treatments may increase hip fracture risk in patients with kidney failure

Erythropoietin treatments may increase hip fracture risk in patients with kidney failure
Hip fracture risk and mean EPO dose per week 1997 - 2013. Credit: Dr. Noguchi

Erythropoietin (EPO) is a medication used to stimulate the production of new red blood cells, which is impaired in individuals with kidney failure. Unfortunately, however, the treatment may increase the risk of hip fractures.

In an published in the Journal of Bone and Mineral Research that examined 1997-2013 records from two large U.S. databases, investigators found that EPO doses administered to patients with on hemodialysis fluctuated widely over time, and hip fracture rates closely tracked the average dose of EPO doses used in patients.

"Patients with can benefit from EPO treatment; however, as with all medications, a full understanding of potential drug-associated risks favors the likelihood that a positive risk-benefit balance can be achieved with EPO treatment," senior author Constance Tom Noguchi, Ph.D., of the National Institute of Diabetes and Digestive and Kidney Diseases.


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More information: Journal of Bone and Mineral Research (2021). DOI: 10.1002/jbmr.4297
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Citation: Erythropoietin treatments may increase hip fracture risk in patients with kidney failure (2021, May 5) retrieved 21 June 2021 from https://medicalxpress.com/news/2021-05-erythropoietin-treatments-hip-fracture-patients.html
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