A fast and inexpensive way to test SARS-CoV-2 antibody levels in human patients

A fast and inexpensive way to test SARS-CoV-2 antibody levels in human patients
Fig. 1. Scheme of the portable sensing system and the gate modification processes of the IgG sensor. The device is connected to a portable meter that is controlled by a mobile phone through Bluetooth. The biological modification on a gate electrode is carried out with several steps. Credit: DOI: 10.1126/sciadv.abg8387

A team of researchers at The Hong Kong Polytechnic University has developed what they describe as a fast and inexpensive way to test for SARS-CoV-2 antibodies in human patients. The results are published in the journal Science Advances.

When a person becomes infected by the SARS-CoV-2 virus, their responds by creating antibodies as one of the ways to fight the infection. The immune system continues to produce such antibodies long after the infection has been cleared. Unfortunately, it is still not known just how long the body continues to make them; thus, discussions regarding when to administer booster shots have become heated in recent weeks. A possible way to reduce such discourse and to relieve the minds of patients, would be access to a cheap and readily available testing that could measure the level of antibodies produced by a given individual. Such a device would also be able to report if a person had previously been infected with the SARS-CoV-2 virus, or if they had been vaccinated against it. In this new effort, the researchers in Hong Kong are claiming to have created just such a device.

The new device is based on the use of organic electrochemical transistors‚ÄĒtypes of transistors that drain current controlled by ions in an electrolyte after injection into a conductor. In this case, the researchers were able to use them to convert bio-signals in to that could be analyzed using software running on a smartphone. To make use of the transistors, the researchers placed them inside individual plastic strips which were then fitted onto a housing. During use, a drop of blood or saliva would be placed on the strip, allowing the transistor to do its work. Making it even easier to use, the researchers used Bluetooth so testing could be done wirelessly. Once the analysis begins, results can be returned in as little as five minutes. The researchers claim that that the plastic strips cost as little as US $1.

The researchers have tested their device and have found it to be highly accurate when analyzing both blood and saliva samples. They have also already made arrangements for their device to begin as soon as possible.


Explore further

Rapid and sensitive on-site measurement of antibodies against the COVID-19 virus

More information: Hong Liu et al, Ultrafast, sensitive, and portable detection of COVID-19 IgG using flexible organic electrochemical transistors, Science Advances (2021). DOI: 10.1126/sciadv.abg8387
Journal information: Science Advances

© 2021 Science X Network

Citation: A fast and inexpensive way to test SARS-CoV-2 antibody levels in human patients (2021, September 16) retrieved 18 October 2021 from https://medicalxpress.com/news/2021-09-fast-inexpensive-sars-cov-antibody-human.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
138 shares

Feedback to editors