Researchers find new treatment for HPV-associated oral cancer

throat cancer
Credit: Pixabay/CC0 Public Domain

Mayo Clinic researchers have found that a new, shorter treatment for patients with HPV-associated oropharynx cancer leads to excellent disease control and fewer side effects, compared to standard treatment.

The new treatment employs minimally invasive surgery and half the standard dose of therapy, compared to current treatments. The new treatment also lasts for two weeks, rather than the standard six weeks.

Results of a study of the new treatment were presented Tuesday, Oct. 20, at the American Society for Radiation Oncology's Annual Meeting.

"Throat caused by HPV is one of the fastest-growing cancer types in the United States," says Daniel J. Ma, M.D., a radiation oncologist at Mayo Clinic and the study's author.

Dr. Ma says that while the for this type of cancer leads to high cure rates, it may also result in many short-term and long-term treatment toxicities, including dry mouth, problems swallowing, neck stiffness and jawbone problems.

"Many of these side effects are directly linked to the amount of radiation used for treatment," says Dr. Ma.

Dr. Ma and his colleagues developed an initial clinical trial looking at a new treatment using minimally invasive surgery and half the standard dose of radiation. The initial clinical trial demonstrated that well-selected patients could have excellent disease control with much lower toxicity using the new treatment.

"Our findings suggest that in select patients with HPV-associated oropharynx a shorter course treatment, compared to the standard of care, yields a similar result," says Dr. Ma. Based on these phase 3 results, Mayo Clinic has adopted this shorter course treatment as its standard of care for well-selected patients.

Dr. Ma and his colleagues are now developing future clinical trials that will test whether it is possible to combine lower doses of radiation with other strategies, such as proton beam therapy, to further reduce toxicity to patients.

Provided by Mayo Clinic
Citation: Researchers find new treatment for HPV-associated oral cancer (2021, October 26) retrieved 21 June 2024 from https://medicalxpress.com/news/2021-10-treatment-hpv-associated-oral-cancer.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

New therapy shortens treatment for HPV-related cancers of the tonsils, tongue

18 shares

Feedback to editors