New study shows non-opioids provide effective pain relief after knee surgery

knee pain
Credit: Pixabay/CC0 Public Domain

A study by Henry Ford Health System published in the October issue of The American Journal of Sports Medicine provides a promising answer to the question "Can patients effectively manage their pain after ACL knee reconstruction surgery without opioids?"

A novel opioid-free pain management protocol developed by Henry Ford sports medicine physicians provided the same for patients as common types of prescription opioids like morphine, hydrocodone, and oxycodone.

"The constitutes practice changing research," said Vasilios (Bill) Moutzouros, M.D., chief of Sports Medicine at Henry Ford and the study's lead author. "The data is powerful in showing we can do such a complex surgery and control post-operative pain without the need for ."

The involved 62 patients who underwent anterior cruciate ligament reconstruction between February 2019 and January 2020. Of those patients, 28 received opioids for pain control and 34 received opioid-free pain medicines that included nonsteroidal anti-inflammatories, acetaminophen, and muscle relaxers. Researchers reported that pain scores from the opioid-free group were equivalent to those who received opioids to manage their pain There were no significant differences in side effects between the two groups. Drowsiness and constipation were the most adverse side effects in both groups.

Studies have shown that patients can become addicted to their opioid medications after various types of surgery including ACL reconstruction. "Our non-opioid approach is a pro-active response to advancing pain management practices for our patients," Dr. Moutzouros said.

"ACL injury patients and parents of young patients really appreciate the ability to have surgery and have no concern of opioid exposure and chance of misuse.". 

In response to the opioid epidemic and ongoing efforts to reduce opioid misuse, Dr. Moutzouros sees the study's findings as another important step toward the reduction and potential elimination of addictive opioids for pain management of all types of surgeries.

The study resulted from Henry Ford's broader initiative launched in 2016 to reduce the number of opioid pills and patches. In 2019, the State of Michigan enacted new laws regulating the prescribing and dispensing of controlled substances including opioid painkillers. From 1999 to 2016, Michigan saw a 17% increase in fatal prescription drug and overdoses.

More information: Vasilios Moutzouros et al, Can We Eliminate Opioids After Anterior Cruciate Ligament Reconstruction? A Prospective, Randomized Controlled Trial, The American Journal of Sports Medicine (2021). DOI: 10.1177/03635465211045394

Citation: New study shows non-opioids provide effective pain relief after knee surgery (2021, November 17) retrieved 17 April 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Researchers say prescribing opioids for pain relief after knee surgery is unnecessary


Feedback to editors