The challenge of organ transplant rejection

pediatric heart
Credit: Pixabay/CC0 Public Domain

Acute rejection of a transplanted organ by the recipient's immune system remains one of the leading causes of pediatric heart transplant failure. While there have been vast improvements in the practice over time, significant variation still exists between transplant centers in the methods used to diagnose acute rejection.

Justin Godown, MD, and colleagues analyzed rejection prevalence and diagnostic practices in pediatric heart . Reporting in the Journal of Heart and Lung Transplantation, they found that 22% of pediatric heart patients experienced an episode of rejection in their first year after transplant, most frequently within the first three months.

Most of these episodes were diagnosed using surveillance biopsy. Despite significant differences in methods used to diagnose between centers, overall graft survival and patient outcomes did not appear to be impacted by these differences.

Minimizing practice variation and creation of standardized surveillance protocols may help inform the identification of best practices in pediatric heart transplants, the researchers concluded.

More information: J. Godown et al, Practice variation in the diagnosis of acute rejection among pediatric heart transplant centers: An analysis of the pediatric heart transplant society (PHTS) registry, The Journal of Heart and Lung Transplantation (2021). DOI: 10.1016/j.healun.2021.08.002

Citation: The challenge of organ transplant rejection (2021, November 15) retrieved 30 May 2024 from
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