Persistent viral shedding common in hospitalized COVID-19 patients

Persistent viral shedding common in hospitalized COVID-19 patients

For patients hospitalized with COVID-19, persistent viral shedding occurs frequently and is associated with in-hospital delirium and increased six-month mortality, according to a study published online May 11 in GeroScience.

Ayush Batra, M.D., from the Northwestern University Feinberg School of Medicine in Chicago, and colleagues conducted a retrospective analysis of persistent viral shedding among Northwestern Medicine Healthcare between March and August 2020. Predictors of persistent viral shedding, in-hospital delirium, and six-month mortality were examined.

The researchers found that 959 of the 2,518 hospitalized patients with a confirmed diagnosis of COVID-19 underwent repeat severe acute respiratory syndrome coronavirus 2 reverse transcription-polymerase chain reaction (RT-PCR) assay testing at least 14 days from initial positive testing. Of these, 42.2 percent had persistent viral shedding. There were associations seen for persistent viral shedding with male sex, increased , , , and exposure to corticosteroids during initial COVID-19 hospitalization. After adjustment for factors, including severity of respiratory dysfunction, persistent viral shedding was independently associated with the incidence of in-hospital delirium (odds ratio, 2.45). The association between persistent viral shedding and increased six-month mortality remained significant even after adjustment for age, severity of respiratory dysfunction, and occurrence of in-hospital delirium (odds ratio, 2.43).

"We were intrigued to see the strong and large association between persistent viral shedding and long-term posthospital mortality, even after adjusting for age, severity of respiratory dysfunction, and presence of ," Batra said in a statement. "This suggests that the presence of persistently positive RT-PCR tests has important clinical implications for patients."


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Citation: Persistent viral shedding common in hospitalized COVID-19 patients (2022, May 13) retrieved 23 May 2022 from https://medicalxpress.com/news/2022-05-persistent-viral-common-hospitalized-covid-.html
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