Repeated concussions can thicken the skull, study finds

Repeated concussions can thicken the skull, study finds
Schematic of study timeline. Rats received 0–3× mTBI impacts or sham procedures spaced 24 h apart. Animals were euthanized at either 2 weeks (sham, 1× mTBI, 2× mTBI and 3× mTBI groups) or 10 weeks (sham and 2× mTBI groups), with the time point referring to time following the last mTBI/sham procedure for collection of skull bones for microCT and histology. Illustrations depict the site of impact of the weight drop model on the rat skull, from a sagittal and dorsal view, respectively. Time points were chosen based upon previous findings in this model, whereby 2× mTBI animals often showed the greatest effects compared to sham controls. Credit: Scientific Reports (2022). DOI: 10.1038/s41598-022-18643-5

New research has found that repeated concussions can thicken the structure of skull bones. Previous studies have shown damage to the brain following concussion, but have not looked at the brain's protective covering.

A Monash-led study published in the journal Scientific Reports by Associate Professor Bridgette Semple from the Monash University's Central Clinical School Department of Neuroscience, found that repeated concussions resulted in thicker, denser bones in the skull.

It is unclear whether this thickening of the skull is a good thing or a bad thing. In theory, a thicker skull is a stronger skull, suggesting that this may be the bone's attempt to protect the brain from subsequent impacts.

"This is a bit of a conundrum," Associate Professor Semple said. "As we know, repeated concussions can have negative consequences for and function. Regardless, concussion is never a good thing."

The team hopes that the microstructural skull alterations caused by are now considered by researchers in the field to better understand how concussions affect the whole body.

Concussion is a form of mild traumatic brain injury, and repeated concussions have been linked to long-term neurological consequences.

Most studies focus on understanding how these affect the brain and its function—but they largely ignore the overlying skull bones that protect the brain.

Although bones are considered a mostly structural component of the human body, bones are in fact active living tissues that can respond to applied mechanical forces.

Study collaborator Professor Melinda Fitzgerald, from Curtin University and the Perron Institute in Western Australia, has previously shown that repeated concussive impacts lead to subtle problems with memory, and evidence of brain damage.

In this new study, high-resolution neuroimaging and tissue staining techniques were used in a pre-clinical model, and revealed an increase in bone thickness and density, in close proximity to the site of injury.

"We have been ignoring the potential influence of the skull in how concussive impacts can affect the brain," Associate Professor Semple said. "These new findings highlight that the skull may be an important factor that affects the consequences of repeated concussions for individuals."

Future studies are planned, with collaborator and bone expert Professor Natalie Sims from St Vincent's Institute of Medical Research in Melbourne, to understand if a thickened skull resulting from repeated concussions alters the transmission of impact force through the and into the vulnerable tissue underneath.

More information: Larissa K. Dill et al, Localized, time-dependent responses of rat cranial bone to repeated mild traumatic brain injuries, Scientific Reports (2022). DOI: 10.1038/s41598-022-18643-5

Journal information: Scientific Reports
Provided by Monash University
Citation: Repeated concussions can thicken the skull, study finds (2022, September 2) retrieved 23 June 2024 from
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