Predominant gonorrhea lineage in Europe is resistant to first-line treatments

Predominant gonorrhea lineage in Europe is resistant to first-line treatments
Concordance between antimicrobial minimum inhibitory concentrations (phenotypes) and genetic determinants of AMR (genotypes, single or in combination) in the Euro-GASP 2018 genomic dataset. Minimum inhibitory concentrations (mg/L) of four key antibiotics showed by the combinations of known genetic AMR determinants observed in 2375 Neisseria gonorrhoeae isolates. X-axis shows the AMR determinants (black dots linked with a solid black line to indicate their presence in combination) and y-axis the minimum inhibitory concentrations (colored dots, where size of dot indicates number of isolates). Violins are colored to indicate different combinations of AMR determinants. Dashed horizontal lines represent the epidemiological cut-off for azithromycin and clinical resistance breakpoints for ciprofloxacin, cefixime, and ceftriaxone established by the European Committee on Antimicrobial Susceptibility Testing. AMR=antimicrobial resistance. Euro-GASP=European Gonococcal Antimicrobial Surveillance Program. Credit: The Lancet Microbe (2022). DOI: 10.1016/S2666-5247(22)00044-1

A study featuring the participation of Fisabio (Foundation for the Promotion of Health and Biomedical Research of Valencia Region), dependent on the Conselleria de Sanitat Universal i Salut Pública, has found that the predominant lineage in Europe of gonococcus—the bacterium which causes gonorrhea—is resistant to one of the two drugs, among others, most commonly used today to treat this disease.

The bacterium Neisseria gonorrhoeae, commonly known as gonococcus, is the cause of gonorrhea, a that is estimated to affect 82 million people worldwide each year. In this context, surveillance of its lineages is necessary to establish the most effective treatments with .

Leonor Sánchez-Busó, a researcher at Fisabio and Plan GenT of the Conselleria de Sanitat Universal i Salut Pública, says, "Compared to two previous surveillance programs, the results of this genomic surveillance study show the expansion of a lineage throughout Europe that is resistant to azithromycin, which compromises the most common treatment for these infections."

This study is an resulting from a resistance surveillance program within the framework of the European Gonococcal Antimicrobial Surveillance Program (Euro-GASP) organized by the European Center of Disease Prevention and Control and in which the Center for Genomic Pathogen Surveillance (Oxford University, United Kingdom), the U.K. Health Protection Agency (London, United Kingdom) and the World Health Organization Collaborating Center in Örebro University Hospital (Sweden) also participated.

The methodology consisted of genomic sequencing and the analysis of 2,375 gonococcus isolates collected in 2018 in 26 countries of the European Economic Area. With this material, links between different genomic lineages, antimicrobial resistance and epidemiological information have been analyzed.

"This lineage contains in its genome a mosaic in the mtrCDE efflux pump that causes resistance to azithromycin, and is significantly associated with pharyngeal infections in risk groups. Fortunately, this collection from 2018 does not show mutations that could compromise treatment of this infection with potential new antibiotics, such as zoliflodacin or gepotidacin," explains Sánchez-Busó, lead author of the article.

The study has been published in The Lancet Microbe and will be of great importance to study the introduction and dynamics of lineages with resistance to antibiotics in Europe as well as in the Valencian Community. One of the researcher's lines of work is this resistance in the Valencian Community, for which she collaborates with the hospitals of the Valencian public network.

Specifically, 13 hospitals in the community have collaborated or will soon collaborate in supplying samples for gonococcus surveillance tasks. In the province of Valencia, the Hospital Universitario de la Ribera, the Hospital Universitario y Politécnico La Fe, the Hospital General Universitario in València, the Hospital Comarcal Francesc de Borja, the Hospital Clínico Universitario in Valencia, the Hospital Arnau de Vilanova, the Hospital Universitario Doctor Peset and the Hospital Lluís Alcanyís in Xàtiva and the Hospital de Manises.

In the rest of the territory, the Hospital Universitario Sant Joan in Alicante, the Hospital Universitario de La Plana, the Hospital General Universitario in Castellón and the Hospital Comarcal in Vinaròs contribute or will contribute to the research. In addition, work continues on the incorporation of new centers that allow better coverage of the entire territory of the Valencian Community.

More information: DOI: 10.13039/501100011033. Leonor Sánchez-Busó et al, Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance study, The Lancet Microbe (2022). DOI: 10.1016/S2666-5247(22)00044-1

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Citation: Predominant gonorrhea lineage in Europe is resistant to first-line treatments (2022, September 19) retrieved 25 March 2023 from
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