New insights into medicines for preeclampsia

New insights into medicines for preeclampsia
Stakeholders' distribution by WHO global regions. The proportion of stakeholders who participated in the (A) interviews (n = 23) and (B) survey (n = 46), in each of the WHO global regions. AFR = African region (yellow), AMR = Region of the Americas (blue), SEAR = South-East Asian region (light green), EUR = European region (red), EMR = Eastern Mediterranean region (dark green), WPR = Western Pacific region (black). Credit: PLOS Global Public Health (2022). DOI: 10.1371/journal.pgph.0001260

Burnet Institute researchers have led the development of the first global strategic guidelines—called target product profiles (TPPs)—for medicines to prevent and treat preeclampsia, a hypertensive disorder in pregnancy that's one of the leading causes of maternal deaths, stillbirth, and preterm birth globally.

Published in the journal PLOS Global Public Health, the TPPs will help to address a longstanding dearth of innovation, and research and development of new medicines for mothers, particularly for pregnancy-related conditions.

"Of the 300,000 global maternal deaths each year, 14 percent are due to hypertensive disorders, of which preeclampsia is the most common," Dr. McDougall, a Senior Research Officer in Burnet's Global Women's and Newborn's Health program, said.

"The vast majority of these deaths happen in low- and middle-income countries where women don't always have access to even the limited amount of medicines and quality of care available in .

"So, in many cases, the only effective course of action is to deliver the baby, which also makes preeclampsia one of the leading causes of preterm birth."

Developed through a process of consensus involving interviews, surveys, and feedback with global stakeholders, the new TPPs provide a detailed description of what new medicines for preeclampsia need to achieve to meet the needs of women and their , particularly with a view to global implementation.

The TPPs would be used by to inform the development of new drugs and products, and to assist funding agencies in their decision making.

"We found there's a high consensus globally on what these new medicines need to look like to be globally implemented," Dr. McDougall said.

"Using that information, we've identified the seven medicines with the highest priority, and eight that show medium potential, and this is where the field should be looking to in terms of where the next preeclampsia medicines might be coming from."

Dr. McDougall said women globally stand to benefit enormously from new medicines to prevent or treat preeclampsia.

"Women in Australia and the US or UK are less likely to die from preeclampsia, but their babies are still being born pre-term," she said.

"But we're trying to ensure that women in low- and at risk of don't miss out on new innovations."

More information: Annie Ra Mcdougall et al, Target product profiles for novel medicines to prevent and treat preeclampsia: An expert consensus, PLOS Global Public Health (2022). DOI: 10.1371/journal.pgph.0001260

Journal information: PLOS Global Public Health
Provided by Burnet Institute
Citation: New insights into medicines for preeclampsia (2022, November 22) retrieved 27 February 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Babies born to mothers with preeclampsia found to be at increased risk of stroke and heart disease later in life


Feedback to editors