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AI model aims to predict how medicines taste

pill on tongue
Credit: Unsplash/CC0 Public Domain

A team from the UCL Global Business School for Health (GBSH) and the UCL School of Pharmacy are using data collected from an "electric tongue" to create an AI model for predicting the bitterness of drugs.

Taste is key to making sure people regularly take their medications and is an important part of . For example, taste has been identified as the biggest barrier in compliance for children taking medicine, but taste is also an issue for adults, especially adults taking long-term medication, such as for HIV.

A research team led by Dr. Hend Abdelhakim (UCL Global Business School for Health) used an e-tongue (a device made of sensors responding to taste) to assign bitterness scores to medicines, and in turn estimate the aversiveness expected from the clinical dose planned.

The e-tongue measures how much the bitter molecules stick on a plastic sensor that acts like the human tongue, and then it compares it with a clear sample. The difference between the two measurements represents a theoretical bitterness level of a medicine.

Using an e-tongue means drugs can be tested more quickly and effectively compared to the alternative option of conducting a , but now the team are collaborating with machine learning experts including Dr. David Shorthouse (UCL School of Pharmacy) to speed up drug development further using an AI model.

Using data from the e-tongue, the AI model breaks down a drug into a series of molecular descriptors (e.g., number of atoms, total surface area of the molecule) that determine taste in order to predict levels of bitterness.

The model being developed will be an open access tool, meaning that pharmaceutical development around the world can benefit from the data on palatability of medicines.

Dr. Abdelhakim said, "We run a machine learning algorithm to basically see what's the , what's the , what are the other chemical physical parameters that make it bitter, and try to see if there's a relationship."

Dr. Abdelhakim explained that taste in medicines was especially a problem for children who have a "heightened sense of taste."

"It's a problem for longer term diseases, so for example, HIV," explained Dr. Abdelhakim. "Antiretroviral medicines don't very well. So, if the patient has to take those pills every day for life, it's a much bigger problem, especially if they start them very, very young.

"Even if it's a wonder , if the patient doesn't take it, it won't work."

Treatment adherence is also particularly important with antibiotics as an interrupted course of treatment will contribute to antimicrobial resistance.

"With , if the patient doesn't take it, yes, they won't get better. But also you're going to contribute to antimicrobial resistance," said Dr. Abdelhakim. "It's actually a bigger problem for the rest of us."

Citation: AI model aims to predict how medicines taste (2023, September 22) retrieved 28 November 2023 from
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