This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:


reputable news agency


Roy Calne, a surgeon who led Europe's first liver transplant, has died aged 93

Roy Calne, a surgeon who led Europe's first liver transplant, has died aged 93
Sir Roy Calne, of Cambridge University, delivers an acceptance speech after receiving the 2012 Lasker DeBakey Clinical Medical Research Award for developing liver transplantation, an intervention that has restored normal life to thousands of patients with end-stage liver disease, Friday, Sept. 21, 2012 in New York. Roy Calne, a pioneer of organ transplantation who led Europe’s first liver transplant surgery in 1968, has died aged 93. Credit: AP Photo/Mary Altaffer, File

Roy Calne, a pioneer of organ transplantation who led Europe's first liver transplant operation in 1968, has died aged 93.

Calne's family said he died late Saturday in Cambridge, England, where he was professor emeritus of surgery at Cambridge University.

Born in 1930, Calne trained as a doctor at Guy's Hospital in London and developed an interest in in the 1950s—partly inspired, he later said, by his father's work as a car mechanic. At the time he was told the procedure would be impossible.

He is considered one of the fathers of organ transplantation, alongside American scientist Dr. Thomas Starzl. Their work on the and treatment to prevent organ rejection was done initially on dogs. In 1960, Calne's dog experiments demonstrated for the first time that a drug could fend off organ rejection. Starzl attempted the first human liver transplant in 1963. That patient died during the procedure.

The next several patients also died within weeks of their transplants, but the surgeries showed that transplanted livers could function.

"It was terrible at the beginning. We had so many dreadful complications," Calne said in 1999.

In May 1968, Calne led a transplant operation on a 46-year-old woman with , at Addenbrooke's Hospital in Cambridge. The patient died two months later of an infection resulting from the given to prevent rejection.

Calne focused on finding better ways to stop patients' bodies rejecting donor organs. He helped develop the breakthrough anti-rejection drug cyclosporine and was the first physician to administer it to transplant patients.

Anti-rejection drugs transformed patients' survival chances, and have saved thousands of lives since they gained wide acceptance in the 1980s.

Calne also helped carry out the world's first triple liver, lung and in 1986 and in 1994 led a six-organ transplant of liver, kidney, stomach, duodenum, small intestine and pancreas.

In 1974, Calne was elected as a Fellow of the Royal Society, the British national academy of science, and was knighted by Queen Elizabeth II in 1986.

In 2012, Calne and Starzl shared the prestigious Lasker Award for their research. In 2021, Addenbrooke's Hospital named its unit, one of Britain's largest, after Calne.

Calne was also an accomplished artist who painted portraits of dozens of his patients and medical colleagues.

© 2024 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission.

Citation: Roy Calne, a surgeon who led Europe's first liver transplant, has died aged 93 (2024, January 8) retrieved 24 April 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Liver transplant surgical pioneer Dr. Thomas Starzl dies


Feedback to editors