This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

fact-checked

trusted source

proofread

Researchers ID potential cause behind the blood vessel dysfunction in obesity

Researchers ID Potential Cause behind the Blood Vessel Dysfunction in Obesity
Graphical abstract. Credit: Function (2024). DOI: 10.1093/function/zqae029

Obesity is a metabolic disorder tied to endothelial dysfunction and increased risk of cardiovascular disease. A recent study, published in the journal Function, investigated the mechanisms responsible for lipid transport and storage interaction with body fat and its impact on metabolic function.

Single-cell RNA sequencing revealed enrichment of fatty acid-handling machinery in blood vessels and endothelial cells from mice that were fed a high-fat diet, indicating their specialized role in lipid metabolism. Phosphorylation of the gap junction protein called Connexin 43, which is involved in intercellular communication and regulates cell proliferation and cell death, increased in the mice and lipid-treated endothelial cells.

These findings suggest Connexin 43-mediated multicellular communication is a possible regulator of fat tissue function. "This increased channel phosphorylation and decreased [] to adipocyte communication, leading to dyslipidemia could be a potential mechanism behind the onset in obesity," the research team wrote.

More information: Melissa A Luse et al, Endothelial-adipocyte Cx43 mediated gap junctions can regulate adiposity, Function (2024). DOI: 10.1093/function/zqae029

Citation: Researchers ID potential cause behind the blood vessel dysfunction in obesity (2024, June 11) retrieved 21 June 2024 from https://medicalxpress.com/news/2024-06-id-potential-blood-vessel-dysfunction.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Biomarker found to help identify cells that can repair damaged blood vessels

0 shares

Feedback to editors